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Article
Baseline brain function in the preadolescents of the ABCD Study
The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopme...
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Article
Open AccessA direct test of the diathesis–stress model for depression
The diathesis–stress theory for depression states that the effects of stress on the depression risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects on the liability...
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Article
Genome-wide association study identifies a novel locus for cannabis dependence
Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of genome-wide association study data on 2080 cannabis-depe...
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Article
Open AccessGenetic effects influencing risk for major depressive disorder in China and Europe
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity...
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Article
Erratum: Meta-analysis of genome-wide association studies of anxiety disorders
Correction to: Molecular Psychiatry (2015); advance online publication 12 January 2016; doi:10.1038/mp.2015.197 Following publication of the above article, the authors noticed that the fifteenth author’s name ...
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Article
Meta-analysis of genome-wide association studies of anxiety disorders
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common, etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic definitions based on cli...
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Article
Evidence of CNIH3 involvement in opioid dependence
Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide association study in Comorbidity and Trauma Study data co...
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Article
Open AccessGenome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psycholog...
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Article
Open AccessGenome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures
Age at onset of alcohol dependence (AO-AD) is a defining feature of multiple drinking typologies. AO-AD is heritable and likely shares genetic liability with other aspects of alcohol consumption. We examine wh...
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Article
Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide...
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Article
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW)...
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Article
Genetic predisposition to schizophrenia associated with increased use of cannabis
Cannabis is the most commonly used illicit drug worldwide. With debate surrounding the legalization and control of use, investigating its health risks has become a pressing area of research. One established as...
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Article
Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample
Smoking is a major risk factor for several somatic diseases and is also emerging as a causal factor for neuropsychiatric disorders. Genome-wide association (GWA) and candidate gene studies for smoking behavior...
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Article
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53
Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of the genetic vulnerability. The goal of the present ...
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Article
Open AccessMonozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin
Our understanding of major depressive disorder (MDD) has focused on the influence of genetic variation and environmental risk factors. Growing evidence suggests the additional role of epigenetic mechanisms inf...
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Article
Erratum: The genetics of addiction—a translational perspective
Correction to: Translational Psychiatry (2012) 2, e140; doi:10.1038/tp.2012.54; published online 17 July 2012 As the result of an editing error, two check marks were omitted from Box 1. In the ‘DSM-5’ column, ...
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Article
Open AccessGenome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top...
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Article
Open AccessMulti-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder
Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite years of effort, recent genome-wide association studies (GWAS) ...
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Article
Open AccessThe genetics of addiction—a translational perspective
Addictions are serious and common psychiatric disorders, and are among the leading contributors to preventable death. This selective review outlines and highlights the need for a multi-method translational app...
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Article
Erratum: Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion
Correction to: Translational Psychiatry (2012) 2, e102; doi:10.1038/tp.2012.27; published online 17 April 2012 Following the online publication of this article, the authors noted that the affiliation for Dr A ...
