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Article
Open AccessA DNA methylation biomarker of alcohol consumption
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of ...
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Article
Open AccessAn epigenome-wide association study meta-analysis of educational attainment
The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that ...
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Article
Open Access708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits
A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and recurrent major depressive disorder (rMDD) in a single lar...
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Article
Open AccessMonozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin
Our understanding of major depressive disorder (MDD) has focused on the influence of genetic variation and environmental risk factors. Growing evidence suggests the additional role of epigenetic mechanisms inf...
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Article
Horn type and horn length genes map to the same chromosomal region in Soay sheep
The evolution of male weaponry in animals is driven by sexual selection, which is predicted to reduce the genetic variability underlying such traits. Soay sheep have an inherited polymorphism for horn type in ...
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Article
Family-based mitochondrial association study of traits related to type 2 diabetes and the metabolic syndrome in adolescents
There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case–control mitochondrial association studies have been undertaken for ...
