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  1. No Access

    Article

    Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence

    Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with se...

    D B Hancock, Y Guo, G W Reginsson, N C Gaddis, S M Lutz, R Sherva… in Molecular Psychiatry (2018)

  2. Article

    Open Access

    Neuregulin signaling pathway in smoking behavior

    Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in s...

    R Gupta, B Qaiser, L He, T S Hiekkalinna, A B Zheutlin… in Translational Psychiatry (2017)

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  3. Article

    Open Access

    Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

    Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psycholog...

    S Stringer, C C Minică, K J H Verweij, H Mbarek, M Bernard… in Translational Psychiatry (2016)

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  4. Article

    Open Access

    Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

    We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence in 17 074 ever smokers from five European-...

    D B Hancock, G W Reginsson, N C Gaddis, X Chen, N L Saccone… in Translational Psychiatry (2015)

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  5. No Access

    Article

    Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample

    Smoking is a major risk factor for several somatic diseases and is also emerging as a causal factor for neuropsychiatric disorders. Genome-wide association (GWA) and candidate gene studies for smoking behavior...

    A Loukola, J Wedenoja, K Keskitalo-Vuokko, U Broms, T Korhonen… in Molecular Psychiatry (2014)

  6. No Access

    Article

    DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder

    Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original t...

    W Hennah, P Thomson, A McQuillin, N Bass, A Loukola, A Anjorin… in Molecular Psychiatry (2009)

  7. No Access

    Article

    Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families

    Schizophrenia is a common and complex mental disorder. Hereditary factors are important for its etiology, but despite linkage signals reported to several chromosomal regions in different populations, final ide...

    J Wedenoja, A Loukola, A Tuulio-Henriksson, T Paunio, J Ekelund… in Molecular Psychiatry (2008)

  8. No Access

    Article

    Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background

    The significant worldwide health burden introduced by tobacco smoking highlights the importance of studying the genetic determinants of smoking behavior and the key factor sustaining compulsive smoking, that i...

    A Loukola, U Broms, H Maunu, E Widén, K Heikkilä, M Siivola… in The Pharmacogenomics Journal (2008)