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Article
Open AccessAn epigenome-wide association study meta-analysis of educational attainment
The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that ...
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Article
Open AccessGenetic susceptibility to cardiovascular disease and risk of dementia
Several studies have shown cardiovascular disease (CVD) to be associated with dementia, but it is not clear whether CVD per se increases the risk of dementia or whether the association is due to shared risk facto...
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Article
Open AccessShort telomere length is associated with impaired cognitive performance in European ancestry cohorts
The association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cog...
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Article
Open AccessGenetic overlap between type 2 diabetes and depression in Swedish and Danish twin registries
A bidirectional association between type 2 diabetes (T2DM) and depression has been consistently reported. Depression is associated with worse biomedical outcomes and increased mortality. The mechanisms underly...
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Article
Open AccessImpact of clinical osteoarthritis of the hip, knee and hand on self-rated health in six European countries: the European Project on OSteoArthritis
Osteoarthritis (OA) has been shown to be associated with decreased physical function, which may impact upon a person’s self-rated health (SRH). Only a few studies have examined the association between OA and S...
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Article
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW)...
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Article
The higher frequency of IgA deficiency among Swedish twins is not explained by HLA haplotypes
Serum immunoglobulin A (IgA) concentrations were determined in 12 600 adult Swedish twins, applying a high-throughput reverse-phase protein microarray technique. The prevalence of IgA deficiency (IgAD) was fou...
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Article
Multifactorial analysis of changes in body mass index across the adult life course: a study with 65 years of follow-up
Although the negative consequences on health of being obese are well known, most adults gain weight across the lifespan. The general increase in body mass index (BMI) is mainly considered to originate from beh...
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Article
A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing
Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality of life and loss of independence in old age. We investigated the genetic contribution to individual differences i...
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Article
Body mass index across midlife and cognitive change in late life
High midlife body mass index (BMI) has been linked to a greater risk of dementia in late life, but few have studied the effect of BMI across midlife on cognitive abilities and cognitive change in a dementia-fr...
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Article
Erratum: Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion
Correction to: Translational Psychiatry (2012) 2, e102; doi:10.1038/tp.2012.27; published online 17 April 2012 Following the online publication of this article, the authors noted that the affiliation for Dr A ...
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Article
Open AccessCommon SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion
The personality traits of neuroticism and extraversion are predictive of a number of social and behavioural outcomes and psychiatric disorders. Twin and family studies have reported moderate heritability estim...
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Article
Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci
To identify common loci and potential genetic variants affecting body mass index (BMI, kg m−2) in study populations originating from Europe.
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Article
Overweight in midlife and risk of dementia: a 40-year follow-up study
This study examines whether overweight in midlife increases dementia risk later in life.
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Article
Heritability of impaired balance: a nationwide cohort study in twins
In this large population-based twin study, a self-estimated impaired balance, an important risk factor for osteoporotic fractures, had a modest heritability of 0.27. Individual-specific environmental influence...
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Chapter and Conference Paper
Design Optimization of Conveyor Systems
In this paper an approach to the design of conveyor systems and particular the design of tracks suited for luggage handling systems in airports is presented. The considered system consists of a closed track wi...
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Article
Designing plates for minimum internal resonances
Internal resonance is a nonlinear phenomenon for a structure when the eigenfrequencies of the structure are commensurable or close to being commensurable. Using optimization we have the possibility to control ...
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Article
An optimality criterion for shape optimization in eigenfrequency problems
For a broad class of static problems an optimality criterion of constant energy density at the designed boundary is known. In the present paper we prove a similar criterion for eigenfrequency problems. This op...
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Article
Optimization of holes in plates for control of eigenfrequencies
In this paper we study the optimization of a hole of given area which is placed in the interior of a plate with an arbitrary external boundary. To avoid stress concentrations the shape of the hole must be smoo...
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Article
Optimization of practical trusses with constraints on eigenfrequencies, displacements, stresses, and buckling
In this paper we consider the optimization of general 3D truss structures. The design variables are the cross-sections of the truss bars together with the joint coordinates, and are considered to be continuous...
