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Article
Open AccessThe association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences
Neurodevelopmental abnormalities in neural connectivity have been long implicated in the etiology of schizophrenia (SCZ); however, it remains unclear whether these neural connectivity patterns are associated w...
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Article
Genome-wide association study identifies a novel locus for cannabis dependence
Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of genome-wide association study data on 2080 cannabis-depe...
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Article
An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry
Fast beta (20–28 Hz) electroencephalogram (EEG) oscillatory activity may be a useful endophenotype for studying the genetics of disorders characterized by neural hyperexcitability, including substance use diso...
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Article
Open AccessGenome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipola...
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Article
Open AccessGenome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures
Age at onset of alcohol dependence (AO-AD) is a defining feature of multiple drinking typologies. AO-AD is heritable and likely shares genetic liability with other aspects of alcohol consumption. We examine wh...
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Article
Open AccessGenome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior
Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a c...
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Article
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53
Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of the genetic vulnerability. The goal of the present ...
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Article
Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants
We conducted a systematic study of top susceptibility variants from a genome-wide association (GWA) study of bipolar disorder to gain insight into the functional consequences of genetic variation influencing d...
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Article
ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry
A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low all...
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Article
Genome-wide association study of conduct disorder symptomatology
Conduct disorder (CD) is one of the most prevalent childhood psychiatric conditions, and is associated with a number of serious concomitant and future problems. CD symptomatology is known to have a considerabl...
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Article
Open AccessConvergent functional genomic studies of omega-3 fatty acids in stress reactivity, bipolar disorder and alcoholism
Omega-3 fatty acids have been proposed as an adjuvant treatment option in psychiatric disorders. Given their other health benefits and their relative lack of toxicity, teratogenicity and side effects, they may...
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Article
Erratum: Identifying blood biomarkers for mood disorders using convergent functional genomics
Correction to: Molecular Psychiatry (2009) 14, 156–174; doi: 10.1038/mp.2008.11 Following the publication of the above article, the authors noted a lack of correct alignment of a heatmap and a numbers column d...
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Article
Genome-wide association study of bipolar disorder in European American and African American individuals
To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n=1001 cases; n=1033 contr...
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Article
Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence
Alcohol dependence frequently co-occurs with cigarette smoking, another common addictive behavior. Evidence from genetic studies demonstrates that alcohol dependence and smoking cluster in families and have sh...
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Article
Singleton deletions throughout the genome increase risk of bipolar disorder
An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genom...
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Article
Identifying blood biomarkers for mood disorders using convergent functional genomics
There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the clinicians’ impression is a rate-limiting step in e...
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Article
Association studies of ALOX5 and bone mineral density in healthy adults
Animal studies suggest that arachidonate 5-lipoxygenase (encoded by ALOX5) may be a genetic determinant of bone mineral density. We tested this hypothesis in a sample of healthy men and women and did not find ...
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Article
Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach
We describe a comprehensive translational approach for identifying candidate genes for alcoholism. The approach relies on the cross-matching of animal model brain gene expression data with human genetic linkag...
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Article
Association of the κ-opioid system with alcohol dependence
Opioid receptors and their endogenous peptide ligands play important roles in the reward and reinforcement of drugs such as heroin, cocaine, and alcohol. The binding of dynorphins to the κ-opioid receptor has bee...
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Article
A genome-wide screen for genes influencing conduct disorder
While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage...
