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Article
Open AccessKetone body 3-hydroxybutyrate as a biomarker of aggression
Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight...
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Article
Open AccessNeuregulin signaling pathway in smoking behavior
Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in s...
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Article
Open AccessGenome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psycholog...
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Article
Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample
Smoking is a major risk factor for several somatic diseases and is also emerging as a causal factor for neuropsychiatric disorders. Genome-wide association (GWA) and candidate gene studies for smoking behavior...
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Article
Open AccessMaternal vitamin D status affects bone growth in early childhood—a prospective cohort study
In this prospective study, 87 children were followed up from birth to 14 months with data on maternal vitamin D status during the pregnancy. Postnatal vitamin D supplementation improved vitamin D status but on...
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Chapter and Conference Paper
Counterflow Model for FDS+Evac Simulations
We present a new method for modeling counterflow situations in crowds. Agents, describing individual pedestrians, are set to avoid the moving directions where there is counterflow and prefer the directions wit...
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Chapter and Conference Paper
FDS+Evac: Modelling Pedestrian Movement in Crowds
The recent developments of the evacuation programme FDS+Evac are presented including a counterflow model for continuum crowd modelling. The major new additions are described and some verification and validatio...
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Article
Glycaemic index values in the Finnish food composition database: an approach to standardised value documentation
The glycaemic index (GI) is used to describe the blood glucose-raising potential of carbohydrate-containing foods. Only a few descriptions of the addition of GI values to national food composition databases (F...
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Chapter and Conference Paper
Calcium Dependent Release and Its Regulation in Cardiac Myocytes: Mathematical Model of the RyR Channel
In cardiac myocytes, the calcium flux through the release channels (Ryanodine Receptors; RyRs) defines the transient changes of intracellular calcium corresponding to the trigger, i.e., the transmembrane calci...
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Chapter and Conference Paper
It Takes Two to Tango: Regulation of Sarcoplasmic Reticulum Calcium ATPase by CaMK and PKA in a Mouse Cardiac Myocyte
At the cellular level, one of the most important regulators of myocardial relaxation is the sarcoplasmic reticulum calcium ATPase (SERCA), which is controlled by phosphorylation both directly and indirectly th...
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Article
Serum α- and γ-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus
The aim of our study was to assess the associations of serum α- and γ-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 ...
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Article
Snacks as an element of energy intake and food consumption
An increasing frequency of snacks has been observed in meal pattern studies. Snacks can alter the diet because of their high-energy density and low-nutrient content or on the contrary.
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Article
A Comparison of the Biological and Clinical Features of Invasive Lobular and Ductal Carcinomas of the Breast
Altogether 295 consecutive pure lobular invasive breast cancers diagnosed between 1990 and 1999 in the area of Tampere University Hospital were compared to 295 ductal invasive breast cancers. Biological factor...
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Article
Effect of Lattice Relaxations on the Hyperfine Fields of Heavy Impurities in Fe
We present first-principles calculations of hyperfine fields of heavy impurities in bcc Fe. In particular, the effect of lattice relaxations on the calculated hyperfine fields are studied. The calculations are...
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Article
Evolution of bacterial pathogenesis
The evolution of bacteria is associated with continuous generation of novel genetic variants. The major driving forces in this process are point mutations, genetic rearrangements, and horizontal gene transfer...
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Article
The effect of the apolipoprotein E phenotype on cholesteryl ester transfer protein activity, plasma lipids and apolipoprotein A I levels in hypercholesterolaemic patients on colestipol and lovastatin treatment
Background: Apolipoprotein E (apo E) allele E 4 is associated with high atherogenic lipid levels and coronary heart disease. Cholesteryl ester transfer protein (CETP) transfers cholester...
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Article
Effect of a synthetic prostaglandin E2 analogue, RS-86505-007, on plasma lipids and lipoproteins in patients with moderate hypercholesterolaemia: efficacy and tolerance of treatment and response in different apolipoprotein polymorphism groups
A double-blind, placebo-controlled ascending dose trial was carried out to evaluate the hypocholesterolaemic efficacy and tolerance of RS-86505-007, a prostaglandin E2 analogue, in moderately hypercholesterolaemi...
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Article
A 15.7-min periodicity in OJ287
The BL Lac-type object OJ287, with a redshift z = 0.306 and a luminosity exceeding 1047 erg s−1 at maximum light, is among the brightest and most violently variable objects of its class. Rapid variations, with ti...
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Article
Blood glucose and serum insulin responses to breakfast including guar gum and cooked or uncooked milk in Type 2 (non-insulin-dependent) diabetic patients
The post-prandial blood glucose and serum insulin responses to test meals, each including 300 ml fat-free milk taken separately with the meal or premixed before cooking into the meal consisting of oatmeal porr...
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Article
Pharmacokinetics of propranolol and sotalol in hyperthyroidism
The elimination and bioavailability of two beta-blocking agents, propranolol and sotalol, were studied in 10 thyrotoxic patients, both before and after treatment with iodine-131. Each subject received in rando...
