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Open AccessEvidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study
Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results...
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Article
Erratum: Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer
Correction to: Oncogenesis (2014) 3, e100; doi:10.1038/oncsis.2014.14; published online 21 April 2014 Since the publication of the above manuscript the authors have identified an error in the author list; the ...
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Open AccessMeta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking expression of estrogen and progesterone receptors (ER/PR) and HER2, thus limiting therapy options. We hypothesized that meta-...
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Article
Open AccessFGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF...
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Article
Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women
Basal-like and triple-negative breast cancers usually display a high level of genomic instability and often carry TP53 mutations. Mutations in EGFR have been reported in about 10 % triple-negative tumours from Ch...
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Open AccessEstimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer
Pedigrees with multiple genotyped family members have been underutilised in breast cancer (BC) genetic-association studies. We developed a pedigree-based analytical framework to characterise single-nucleotide ...
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Article
Open AccessGenome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM
Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top...
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Article
Open AccessAssociation of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methyle...
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Open AccessThe use of the Illumina FFPE Restoration Protocol to obtain suitable quality DNA for SNP-based CGH– a pilot study
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Open AccessA multi-center study to evaluate the impact of germline BRCA1 and BRCA2 mutations on ovarian cancer survival
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Open AccessSearching for BRCA3 by exome sequencing
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Open AccessPrimary treatment patterns in women recruited to the Australian Ovarian Cancer Study
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Open AccessCommon genomic variants associated with breast cancer predict the risk of second primary breast cancer diagnosis
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Open AccessThe challenges of finding the gene responsible for a rare, autosomal dominant gastric cancer susceptibility syndrome
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Open AccessIdentification of new breast cancer predisposition genes via whole exome sequencing
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Open AccessAnalysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients
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Open AccessThe Australian Ovarian Cancer Study
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Open AccessEvaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk
Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor recep...
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Article
Folate and related micronutrients, folate-metabolising genes and risk of ovarian cancer
Folates are essential for DNA synthesis and methylation, and thus may have a role in carcinogenesis. Limited evidence suggests folate-containing foods might protect against some cancers and may partially mitig...
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Open AccessEvaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2
Single-nucleotide polymorphisms (SNPs) in genes involved in DNA repair are good candidates to be tested as phenotypic modifiers for carriers of mutations in the high-risk susceptibility genes BRCA1 and BRCA2. The...
