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  1. No Access

    Article

    Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence

    Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with se...

    D B Hancock, Y Guo, G W Reginsson, N C Gaddis, S M Lutz, R Sherva… in Molecular Psychiatry (2018)

  2. No Access

    Article

    Genome-wide association study identifies a novel locus for cannabis dependence

    Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of genome-wide association study data on 2080 cannabis-depe...

    A Agrawal, Y-L Chou, C E Carey, D A A Baranger, B Zhang, R Sherva… in Molecular Psychiatry (2018)

  3. No Access

    Article

    Evidence of CNIH3 involvement in opioid dependence

    Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide association study in Comorbidity and Trauma Study data co...

    E C Nelson, A Agrawal, A C Heath, R Bogdan, R Sherva, B Zhang… in Molecular Psychiatry (2016)

  4. Article

    Open Access

    Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

    Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psycholog...

    S Stringer, C C Minică, K J H Verweij, H Mbarek, M Bernard… in Translational Psychiatry (2016)

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  5. Article

    Open Access

    Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

    We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence in 17 074 ever smokers from five European-...

    D B Hancock, G W Reginsson, N C Gaddis, X Chen, N L Saccone… in Translational Psychiatry (2015)

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  6. Article

    Erratum: Genetic risk prediction and neurobiological understanding of alcoholism

    Correction to: Translational Psychiatry (2014) 4, e391; doi:10.1038/tp.2014.29; published online 20 May 2014 Following publication of the above article, the authors noticed that the twelfth author’s name was m...

    D F Levey, H Le-Niculescu, J Frank, M Ayalew, N Jain, B Kirlin… in Translational Psychiatry (2014)

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  7. No Access

    Article

    Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene

    We report a genome-wide association study (GWAS) for cocaine dependence (CD) in three sets of African- and European-American subjects (AAs and EAs, respectively) to identify pathways, genes and alleles importa...

    J Gelernter, R Sherva, R Koesterer, L Almasy, H Zhao, H R Kranzler… in Molecular Psychiatry (2014)

  8. Article

    Open Access

    Genetic risk prediction and neurobiological understanding of alcoholism

    We have used a translational Convergent Functional Genomics (CFG) approach to discover genes involved in alcoholism, by gene-level integration of genome-wide association study (GWAS) data from a German alcohol...

    D F Levey, H Le-Niculescu, J Frank, M Ayalew, N Jain, B Kirlin… in Translational Psychiatry (2014)

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  9. No Access

    Article

    Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci

    We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-American (AA) populations, with replication in independent samples of EAs, AAs and Germans. Our sample for discovery and replic...

    J Gelernter, H R Kranzler, R Sherva, L Almasy, R Koesterer… in Molecular Psychiatry (2014)