-
Article
Associations between Proportion of Plasma Phospholipid Fatty Acids, Depressive Symptoms and Major Depressive Disorder. Cross-Sectional Analyses from the AGES Reykjavik Study
Deficits in n-3 fatty acids may be associated with depression. However, data are scarce from older adults who are at greater risk of poor dietary intake and of develo** depression.
-
Article
Association of bone turnover markers with volumetric bone loss, periosteal apposition, and fracture risk in older men and women: the AGES-Reykjavik longitudinal study
Association between serum bone formation and resorption markers and cortical and trabecular bone loss and the concurrent periosteal apposition in a population-based cohort of 1069 older adults was assessed. BT...
-
Article
Are bone turnover markers associated with volumetric bone density, size, and strength in older men and women? The AGES–Reykjavik study
Association between serum bone formation and resorption markers and bone mineral, structural, and strength variables derived from quantitative computed tomography (QCT) in a population-based cohort of 1745 old...
-
Article
GWAS for executive function and processing speed suggests involvement of the CADM2 gene
To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information proce...
-
Article
A novel Alzheimer disease locus located near the gene encoding tau protein
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’...
-
Article
Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide...
-
Article
Polyunsaturated fatty acids in relation to incident mobility disability and decline in gait speed; the Age, Gene/Environment Susceptibility-Reykjavik Study
Low intake of long chain polyunsaturated fatty acids (PUFAs) are associated with physical disability; however, prospective studies of circulating PUFAs are scarce. We examined associations between plasma phosp...
-
Article
Lifelong physical activity in maintaining bone strength in older men and women of the Age, Gene/Environment Susceptibility–Reykjavik Study
We examined if lifelong physical activity is important for maintaining bone strength in the elderly. Associations of quantitative computerized tomography-acquired bone measures (vertebral and femoral) and self...
-
Article
Retinopathy in old persons with and without diabetes mellitus: the Age, Gene/Environment Susceptibility—Reykjavik Study (AGES-R)
We aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus.
-
Article
The interaction of adiposity with the CRP gene affects CRP levels: Age, Gene/Environment Susceptibilty-Reykjavik Study
Common diseases often have an inflammatory component reflected by associated markers such as serum C-reactive protein (CRP) levels. Circulating CRP levels have also been associated with adipose tissue as well ...
-
Article
Open AccessChromosome alterations and E-cadherin gene mutations in human lobular breast cancer
We have studied a set of 40 human lobular breast cancers for loss of heterozygosity (LOH) at various chromosome locations and for mutations in the coding region plus flanking intron sequences of the E-cadherin...
-
Article
Open AccessLoss of heterozygosity at chromosome 1p in different solid human tumours: association with survival
The distal half of chromosome 1p was analysed with 15 polymorphic microsatellite markers in 683 human solid tumours at different locations. Loss of heterozygosity (LOH) was observed at least at one site in 369...
-
Article
Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations
We examined DNA from 116 female and four male breast cancer patients for loss of heterozygosity (LOH). DNA was analysed by polymerase chain reaction using ten microsatellite markers on chromosome 11. Three dis...
