14 Result(s)

Article

Disproportionate Rates of COVID-19 Among Black Canadian Communities: Lessons from a Cross-Sectional Study in the First Year of the Pandemic

Racialized communities, including Black Canadians, have disproportionately higher COVID-19 cases. We examined the extent to which SARS-CoV-2 infection has affected the Black Canadian community and the factors ...

Upton D. Allen, Michelle Barton, Julia Upton… in Journal of Racial and Ethnic Health Dispar… (2024)

Article

Author Correction: Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model

Julia Ludwig, Stephen W. Scally, Giulia Costa, Sandro Hoffmann… in npj Vaccines (2023)

Article

Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model

The development of an effective and durable vaccine remains a central goal in the fight against malaria. Circumsporozoite protein (CSP) is the major surface protein of sporozoites and the target of the only li...

Julia Ludwig, Stephen W. Scally, Giulia Costa, Sandro Hoffmann… in npj Vaccines (2023)

Article

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, wh...

Michael G. Sugiyama, Haotian Cui, Dar’ya S. Redka, Mehran Karimzadeh… in Scientific Reports (2021)

Article

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin protomer as a modular subu...

Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir… in Nature Communications (2021)

Article

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

Sialic acid-binding immunoglobulin-type lectins (Siglecs) are immunomodulatory receptors that are regulated by their glycan ligands. The connections between Siglecs and human disease motivate improved methods ...

Emily Rodrigues, Jaesoo Jung, Hea** Park, Caleb Loo… in Nature Communications (2020)

Article

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, and delivers a positive co-stimulatory signal to activated T cells upon binding to its ligand (ICOS-L). Dysregulation of this pathway ...

Edurne Rujas, Hong Cui, Taylor Sicard, Anthony Semesi… in Nature Communications (2020)

Article

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

Transmission-blocking vaccines have the potential to be key contributors to malaria elimination. Such vaccines elicit antibodies that inhibit parasites during their development in Anopheles mosquitoes, thus break...

Brandon McLeod, Kazutoyo Miura, Stephen W. Scally, Alexandre Bosch… in Nature Communications (2019)

Article

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions

Antibodies against the Membrane-Proximal External Region (MPER) of the Env gp41 subunit neutralize HIV-1 with exceptional breadth and potency. Due to the lack of knowledge on the MPER native structure and acce...

Pablo Carravilla, Jakub Chojnacki, Edurne Rujas, Sara Insausti… in Nature Communications (2019)

Article

Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45

Interventions that can block the transmission of malaria-causing Plasmodium falciparum (Pf) between the human host and Anopheles vector have the potential to reduce the incidence of malaria. Pfs48/45 is a gametoc...

Prasun Kundu, Anthony Semesi, Matthijs M. Jore, Merribeth J. Morin… in Nature Communications (2018)

Article

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25

The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies that inhibit parasite development when ingested by An...

Stephen W. Scally, Brandon McLeod, Alexandre Bosch, Kazutoyo Miura… in Nature Communications (2017)

Article

Molecular basis of human CD22 function and therapeutic targeting

CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As a B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that cause autoimmune diseases...

June Ereño-Orbea, Taylor Sicard, Hong Cui… in Nature Communications (2017)

Article

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

The trimeric envelope glycoproteins (Env) on the surface of HIV-1 virions are the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet induced potent, broadly active NAbs (bNAbs). P...

Anila Yasmeen, Rajesh Ringe, Ronald Derking, Albert Cupo… in Retrovirology (2014)

Article

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary s...

Jason S. McLellan, Marie Pancera, Chris Carrico, Jason Gorman… in Nature (2011)