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Article
Open AccessA molecular switch modulates assembly and host factor binding of the HIV-1 capsid
The HIV-1 capsid is a fullerene cone made of quasi-equivalent hexamers and pentamers of the viral CA protein. Typically, quasi-equivalent assembly of viral capsid subunits is controlled by a molecular switch. ...
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Article
Open AccessMultivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin protomer as a modular subu...
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Article
Open AccessProtein rethreading: A novel approach to protein design
Protein engineering is an important tool for the design of proteins with novel and desirable features. Templates from the protein databank (PDB) are often used as initial models that can be modified to introdu...
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Article
Optimizing nanodiscs and bicelles for solution NMR studies of two β-barrel membrane proteins
Solution NMR spectroscopy has become a robust method to determine structures and explore the dynamics of integral membrane proteins. The vast majority of previous studies on membrane proteins by solution NMR h...
