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Article
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage
The central dogma of biology does not allow for the study of glycans using DNA sequencing. We report a liquid glycan array (LiGA) platform comprising a library of DNA ‘barcoded’ M13 virions that display 30–1,5...
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Article
Targeted self-destruction
Altered glycosylation helps cancer cells evade immune destruction, and targeted remodeling of glycans in vivo offers the ability to reprogram immune responses. A stable chemical linkage between an antibody and...
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Article
Open AccessA versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are immunomodulatory receptors that are regulated by their glycan ligands. The connections between Siglecs and human disease motivate improved methods ...
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Article
Open AccessAuthor Correction: Repression of phagocytosis by human CD33 is not conserved with mouse CD33
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessRepression of phagocytosis by human CD33 is not conserved with mouse CD33
CD33 is an immunomodulatory receptor linked to Alzheimer’s disease (AD) susceptibility via regulation of phagocytosis in microglia. Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include...
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Article
Open AccessA quantitative, high-throughput method identifies protein–glycan interactions via mass spectrometry
Glycan binding by glycan-binding proteins and processing by carbohydrate-active enzymes is implicated in physiological and pathophysiological processes. Comprehensive map** of glycan interactions is essentia...
