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Open AccessStructural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b
Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging cancer immunotherapy target. However, limited understanding of its structure and mechanism of action restrains the developm...
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Open AccessThe spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a multi-organ damage that includes hepatic dysfunction, which has been observed in over 50% of COVID-19 patients. Liver injury in COVID-19 co...
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Open AccessMolecular basis of human CD22 function and therapeutic targeting
CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As a B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that cause autoimmune diseases...
