-
Article
Open AccessMultivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic. Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human apoferritin protomer as a modular subu...
-
Article
Open AccessStructural basis of substrate recognition and thermal protection by a small heat shock protein
Small heat shock proteins (sHsps) bind unfolding proteins, thereby playing a pivotal role in the maintenance of proteostasis in virtually all living organisms. Structural elucidation of sHsp-substrate complexe...
-
Article
Open AccessMultiple conformations facilitate PilT function in the type IV pilus
Type IV pilus-like systems are protein complexes that polymerize pilin fibres. They are critical for virulence in many bacterial pathogens. Pilin polymerization and depolymerization are powered by motor ATPase...
-
Article
Structure of a functional obligate complex III2IV2 respiratory supercomplex from Mycobacterium smegmatis
In the mycobacterial electron-transport chain, respiratory complex III passes electrons from menaquinol to complex IV, which in turn reduces oxygen, the terminal acceptor. Electron transfer is coupled to trans...
-
Article
Structure of the alternative complex III in a supercomplex with cytochrome oxidase
Alternative complex III (ACIII) is a key component of the respiratory and/or photosynthetic electron transport chains of many bacteria1–3. Like complex III (also known as the bc1 complex), ACIII catalyses the oxi...
-
Article
Open AccessMolecular basis of human CD22 function and therapeutic targeting
CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As a B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that cause autoimmune diseases...
-
Article
Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase
The structure of the VO subcomplex of yeast V-ATPase, solved by electron cryomicroscopy, reveals a new subunit and suggests a mechanism for the translocation of protons across membranes.
-
Article
The structural basis of modified nucleosome recognition by 53BP1
A cryo-electron microscopy structure of the DNA damage repair protein 53BP1 bound to a nucleosome illuminates the way 53BP1 recognizes two types of histone modifications (a methyl group and a ubiquitin moiety)...
-
Article
Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase
Electron cryomicroscopy shows structures of three distinct rotational states of the V-ATPase from Saccharomyces cerevisiae.
-
Article
Structure of the vacuolar-type ATPase from Saccharomyces cerevisiae at 11-Å resolution
Vacuolar-type ATPases (V-type ATPases) are large integral membrane protein complexes. Their activity acidifies intracellular compartments, and they are regulated by the dissociation of the complex's V1 and VO ...
