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Article
Open AccessImmune mobilising T cell receptors redirect polyclonal CD8+ T cells in chronic HIV infection to form immunological synapses
T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8+ T cells, which may remain dysfun...
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Article
Open AccessAuthor Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells
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Article
Open AccessSARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells
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Article
Open AccessPlasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracell...
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Article
Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry
Several Ebola viruses cause outbreaks of lethal haemorrhagic fever in humans, but develo** therapies tackle only Zaire Ebola virus. Dendritic cells (DCs) are targets of this infection in vivo. Here, we found...
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Article
Open AccessMolecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions
Antibodies against the Membrane-Proximal External Region (MPER) of the Env gp41 subunit neutralize HIV-1 with exceptional breadth and potency. Due to the lack of knowledge on the MPER native structure and acce...
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Chapter and Conference Paper
How Good Is My Project? Experiences from Projecting Software Quality Using a Reference Set
Effective management of a portfolio of software projects may include ranking them with respect to various qualitative criteria. Diversity of projects in terms of their size, maturity and domain poses additiona...
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Article
Open AccessSuper-resolution fluorescence microscopy studies of human immunodeficiency virus
Super-resolution fluorescence microscopy combines the ability to observe biological processes beyond the diffraction limit of conventional light microscopy with all advantages of the fluorescence readout such ...
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Article
Open AccessEnvelope glycoprotein mobility on HIV-1 particles depends on the virus maturation state
Human immunodeficiency virus type 1 (HIV-1) assembles as immature particles, which require the proteolytic cleavage of structural polyprotein Gag and the clustering of envelope glycoprotein Env for infectivi...
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Article
Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics
Temporally stochastic STED nanoscopy with electro-optical deflector–based scanning allows ultrafast super-resolution imaging. The method was used to monitor vesicles and viruses moving at ~2 μm/s with no motio...
