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Article
Open AccessConfinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular si...
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Article
Open AccessMultiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease
The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, wh...
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Article
Open AccessTargeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation
Antibody combinations targeting cell surface receptors are a new modality of cancer therapy. The trafficking and signalling mechanisms regulated by such therapeutics are not fully understood but could underlie...
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Article
Open AccessGenome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
In humans and animals lacking functional LDL receptor (LDLR), LDL from plasma still readily traverses the endothelium. To identify the pathways of LDL uptake, a genome-wide RNAi screen was performed in endothe...
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Article
Open AccessThe Tie2-agonist Vasculotide rescues mice from influenza virus infection
Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administere...
