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Article
Open AccessHuman papillomavirus integration transforms chromatin to drive oncogenesis
Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers. Frequent integration into the host genome occurs predominantly in tumorigenic types of HPV. We hypothesize ...
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Article
Open AccessSingle-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity
Knowledge of the transcriptional programs underpinning the functions of human kidney cell populations at homeostasis is limited. We present a single-cell perspective of healthy human kidney from 19 living dono...
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Article
Open AccessVirtual ChIP-seq: predicting transcription factor binding by learning from the transcriptome
Existing methods for computational prediction of transcription factor (TF) binding sites evaluate genomic regions with similarity to known TF sequence preferences. Most TF binding sites, however, do not resemb...
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Article
Open AccessMultiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease
The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, wh...
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Article
Variation in genomic landscape of clear cell renal cell carcinoma across Europe
The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake whole-genome and transcriptome sequencing of clea...
