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Article
Open AccessEvolutionary modelling indicates that mosquito metabolism shapes the life-history strategies of Plasmodium parasites
Within-host survival and between-host transmission are key life-history traits of single-celled malaria parasites. Understanding the evolutionary forces that shape these traits is crucial to predict malaria ep...
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Article
Open AccessAuthor Correction: Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model
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Article
Open AccessGlycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model
The development of an effective and durable vaccine remains a central goal in the fight against malaria. Circumsporozoite protein (CSP) is the major surface protein of sporozoites and the target of the only li...
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Article
Open AccessOptimization of the Biostabilization Process of an Italian Mechanical–Biological Treatment Plant to Account for Changes in Waste Composition
In this paper, we present a case study on the optimization of the biostabilization process of an Italian mechanical–biological treatment (MBT) plant to account for changes in feed waste composition related to ...
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Reference Work Entry In depth
Protective Agents in Parkinson’s Disease: Caffeine and Adenosine A2A Receptor Antagonists
Based on several findings suggesting that the adenosinergic system is one of the most interesting in the field of neuroprotection in Parkinson’s disease, this chapter describes the functions of the purine aden...
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Article
The Neuroinflammatory and Neurotoxic Potential of Palmitic Acid Is Mitigated by Oleic Acid in Microglial Cells and Microglial-Neuronal Co-cultures
Neuroinflammation has been implicated in the pathogenesis of neurodegeneration and is now accepted as a common molecular feature underpinning neuronal damage and death. Palmitic acid (PA) may represent one of ...
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Living Reference Work Entry In depth
Protective Agents in Parkinson’s Disease: Caffeine and Adenosine A2A Receptor Antagonists
Based on several findings suggesting that the adenosinergic system is one of the most interesting in the field of neuroprotection in Parkinson’s disease, this chapter describes the functions of the purine aden...
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Article
Enhanced Separation of Incinerator Bottom Ash: Composition and Environmental Behaviour of Separated Mineral and Weakly Magnetic Fractions
The paper reports an investigation on the compositional characteristics and environmental behaviour of eight fractions deriving from an advanced separation process applied to waste incineration bottom ash to r...
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Article
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs
The circumsporozoite protein of the human malaria parasite Plasmodium falciparum (PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in animal models. However, the limited ef...
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Article
Accelerated carbonation of wood combustion ash for CO2 removal from gaseous streams and storage in solid form
In this work, ash generated by the combustion of wood in a central heating plant was used to remove and permanently store by accelerated carbonation CO2 contained in a gas mixture simulating biogas. The process w...
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Article
Repeated Administration of 3,4-Methylenedioxymethamphetamine (MDMA) Elevates the Levels of Neuronal Nitric Oxide Synthase in the Nigrostriatal System: Possible Relevance to Neurotoxicity
Previous studies have consistently demonstrated that the amphetamine-related drug 3,4-methylenedioxymethamphetamine (MDMA) induces dopaminergic damage in the mouse brain, and that this effect is most marked in...
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Article
Open AccessNCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson’s Disease
Na+-Ca2+ exchanger (NCX) isoforms constitute the major cellular Ca2+ extruding system in neurons and microglia. We herein investigated the role of NCX isoforms in the pathophysiology of Parkinson’s disease (PD). ...
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Article
Open AccessNeurochemical and Neurotoxic Effects of MDMA (Ecstasy) and Caffeine After Chronic Combined Administration in Mice
MDMA (3,4-methylenedioxymethamphetamine) is a psychostimulant popular as a recreational drug because of its effect on mood and social interactions. MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5...
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Article
Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage
The amphetamine-related drug 3,4methylenedioxymethamphetamine (MDMA) is known to induce neurotoxic damage in dopaminergic regions of the mouse brain. In order to characterize how the number of administrations...
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Article
Granulation–Carbonation Treatment of Alkali Activated Steel Slag for Secondary Aggregates Production
In view of the EU’s circular economy strategy, there is a need to develop treatments that may allow to improve the management of industrial residues such as steel manufacturing slag, for example by producing s...
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Article
Activation of adenosine A2A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic vocalizations in rats: possible relevance to reward and motivation
Rats emit 50-kHz ultrasonic vocalizations (USVs) in response to pleasurable stimuli, and these USVs are considered a tool for investigating reward and motivation.
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Article
Biogas Upgrading by a Combination of Innovative Treatments Based on Carbonation of Waste Incineration Residues
This paper reports the results of experimental tests carried out in a biogas upgrading pilot plant installed in a landfill site based on an innovative process for biomethane production that allows to permanen...
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Article
Erratum to: MDMA administration during adolescence exacerbates MPTP-induced cognitive impairment and neuroinflammation in the hippocampus and prefrontal cortex
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Chapter
Adenosine A2A Receptor Antagonists in L-DOPA-Induced Motor Fluctuations
Motor fluctuations, and in particular dyskinesia, affect a large percentage of parkinsonian patients under dopamine replacement therapy. Adenosine A2A receptor antagonists may be a new strategy for the treatment ...
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Article
The Hypocretin/Orexin System Mediates the Extinction of Fear Memories
Anxiety disorders are often associated with an inability to extinguish learned fear responses. The hypocretin/orexin system is involved in the regulation of emotional states and could also participate in the c...
