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Open AccessPfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody
Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that block Plasmodium parasite development in the mosquito midgut, thus preventing mosquitoes from becoming infectious. While the Pro-domain ...
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Article
Open AccessStructure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies
An effective malaria vaccine remains a global health priority and vaccine immunogens which prevent transmission of the parasite will have important roles in multi-component vaccines. One of the most promising ...
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Article
Open AccessStructure and function of a family of tick-derived complement inhibitors targeting properdin
Activation of the serum-resident complement system begins a cascade that leads to activation of membrane-resident complement receptors on immune cells, thus coordinating serum and cellular immune responses. Wh...
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Article
Open AccessPreclinical development of a Pfs230-Pfs48/45 chimeric malaria transmission-blocking vaccine
The Plasmodium falciparum Pfs230 and Pfs48/45 proteins are leading candidates for a malaria transmission-blocking vaccine (TBV). Previously, we showed that a Pfs230–Pfs48/45 fusion protein elicits higher levels o...
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Article
Open AccessMonoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes
Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (T...
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Article
Open AccessStructural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
Interventions that can block the transmission of malaria-causing Plasmodium falciparum (Pf) between the human host and Anopheles vector have the potential to reduce the incidence of malaria. Pfs48/45 is a gametoc...
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Article
Open AccessStructural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody
The quest to develop an effective malaria vaccine remains a major priority in the fight against global infectious disease. An approach with great potential is a transmission-blocking vaccine which induces anti...
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Article
Open AccessPublisher Correction: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
The original version of this Article contained errors in Fig. 3. In panel a, bars from a chart depicting the percentage of antibody-positive individuals in non-infectious and infectious groups were inadvertent...
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Article
Open AccessUnravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of n...
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Article
Structural basis for therapeutic inhibition of complement C5
Structural and functional analyses of a new family of tick-derived C5 inhibitors in complex with inhibitor OmCI and therapeutic antibody eculizumab reveal diverse mechanisms for inhibition and provide insight ...
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Article
DNA-guided DNA interference by a prokaryotic Argonaute
Here, Argonaute from the prokaryote Thermus thermophilus is shown to use small DNA guides to interfere directly with invading foreign DNA, rather than being involved in RNA-guided RNA interference, as observed in...
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Article
Structures of the RNA-guided surveillance complex from a bacterial immune system
Bacterial cells use CRISPRs (clustered regularly interspaced short palindromic repeats) to defend against invading phages. The central catalytic component in this process is Cascade, a 12-subunit complex consi...
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Article
Structural basis for CRISPR RNA-guided DNA recognition by Cascade
The CRISPR system is a prokaryotic immune system that depends on the Cascade protein complex and small guide RNAs (crRNAs). The Cascade complex, loaded with crRNA, is now characterized, the overall architectur...
