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Open AccessClinical landscape of macrophage-reprogramming cancer immunotherapies
Tumour-associated macrophages (TAMs) sustain a tumour-supporting and immunosuppressive milieu and therefore aggravate cancer prognosis. To modify TAM behaviour and unlock their anti-tumoural potential, novel T...
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Open AccessThe effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients
The role of exercise in cancer prevention and control is increasingly recognized, and based on preclinical studies, it is hypothesized that mobilization of leukocytes plays an important role in the anti-tumor ...
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Article
Open AccessPolymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19
The use of glucocorticoids has given contradictory results for treating acute respiratory distress syndrome (ARDS). The use of intravenous Interferon beta (IFN β) for the treatment of ARDS was recently tested ...
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Open AccessClever-1 positive macrophages in breast cancer
Common Lymphatic Endothelial and Vascular Endothelial Receptor 1 (Clever-1) is expressed by a subset of immunosuppressive macrophages and targeting the receptor with therapeutic antibodies has been shown to ac...
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Open AccessThe tumor and plasma cytokine profiles of renal cell carcinoma patients
Renal cell carcinoma (RCC) accounts for 90% of all renal cancers and is considered highly immunogenic. Although many studies have reported the circulating peripheral cytokine profiles, the signatures between t...
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Open AccessVascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation
Although the development of hematopoietic stem cells (HSC) has been studied in great detail, their heterogeneity and relationships to different cell lineages remain incompletely understood. Moreover, the role ...
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Open AccessRed blood cell transfusion induces abnormal HIF-1α response to cytokine storm after adult cardiac surgery
Patients undergoing cardiac surgery develop a marked postoperative systemic inflammatory response. Blood transfusion may contribute to disruption of homeostasis in these patients. We sought to evaluate the imp...
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Open AccessGlucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung
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Open AccessNew tools to prevent cancer growth and spread: a ‘Clever’ approach
Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes and macrophages. Its role in cancer...
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Open AccessIncreased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology
Lipedema is a chronic adipose tissue disorder characterized by the disproportional subcutaneous deposition of fat and is commonly misdiagnosed as lymphedema or obesity. The molecular determinants of the lipede...
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Open AccessInterferon beta-1a for COVID-19: critical importance of the administration route
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Regulation of CD73 in the development of lower limb atherosclerosis
Atherosclerosis is an inflammatory process of the arterial wall. CD73 (also known as ecto-5′-nucleotidase) is a key regulator of cell signaling in response to inflammation and hypoxia, and may be important in ...
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Open AccessTransgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice
Obesity comprises great risks for human health, contributing to the development of other diseases such as metabolic syndrome, type 2 diabetes and cardiovascular disease. Previously, obese patients were found t...
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Open AccessCharacterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer
Tumor heterogeneity may broadly influence the activation of tumor-associated macrophages. We aimed to dissect how breast cancer cells of different molecular characteristics contribute to macrophage phenotype a...
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Open AccessFingerprinting Breast Cancer vs. Normal Mammary Cells by Mass Spectrometric Analysis of Volatiles
There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile met...
