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Article
Open AccessSustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest in their possible involvemen...
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Article
Open AccessThe angiopoietin receptor Tie2 is atheroprotective in arterial endothelium
Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of endothelial Tie1 receptor tyrosine kinase is enhanced at these sites...
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Article
Open Access3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
Tryptophan catabolism is a major metabolic pathway utilized by several professional and non-professional antigen presenting cells to maintain immunological tolerance. Here we report that 3-hydroxy-l-kynurenamine ...
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Article
Open AccessAlternative transcription of a shorter, non-anti-angiogenic thrombospondin-2 variant in cancer-associated blood vessels
Thrombospondin-2 (TSP2) is an anti-angiogenic matricellular protein that inhibits tumor growth and angiogenesis. Tumor-associated blood vascular endothelial cells (BECs) were isolated from human invasive bladd...
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Protocol
Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery
The lymphatic vessels can be selectively stimulated to grow in adult mice, rats and pigs by application of viral vectors expressing the lymphangiogenic factors VEGF-C or VEGF-D. Vice versa, lymphangiogenesis i...
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Article
Open AccessRegulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling
Lymphatic vessels play important roles in fluid drainage and in immune responses, as well as in pathological processes including cancer progression and inflammation. While the molecular regulation of the earli...
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Article
Open AccessTransgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice
Obesity comprises great risks for human health, contributing to the development of other diseases such as metabolic syndrome, type 2 diabetes and cardiovascular disease. Previously, obese patients were found t...
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Article
Decline of lymphatic vessel density and function in murine skin during aging
Lymphatic vessels play important roles in the pathogenesis of many conditions that have an increased prevalence in the elderly population. However, the effects of the aging process on the lymphatic system are ...
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Article
Open AccessCharacterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer
Tumor heterogeneity may broadly influence the activation of tumor-associated macrophages. We aimed to dissect how breast cancer cells of different molecular characteristics contribute to macrophage phenotype a...
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Chapter
The Role of Neuropilin-1/Semaphorin 3A Signaling in Lymphatic Vessel Development and Maturation
During development, the lymphatic and the blood vascular system form highly branched networks that show extensive architectural similarities with the peripheral nervous system. Increasing evidence suggests tha...
