-
Article
Open AccessPolymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19
The use of glucocorticoids has given contradictory results for treating acute respiratory distress syndrome (ARDS). The use of intravenous Interferon beta (IFN β) for the treatment of ARDS was recently tested ...
-
Article
Open AccessInduction of CD73 prevents death after emergency open aortic surgery for a ruptured abdominal aortic aneurysm: a randomized, double-blind, placebo-controlled study
Mortality remains high after emergency open surgery for a ruptured abdominal aortic aneurysm (RAAA). The aim of the present study was to assess, if intravenous (IV) Interferon (IFN) beta-1a improve survival af...
-
Article
Open AccessRed blood cell transfusion induces abnormal HIF-1α response to cytokine storm after adult cardiac surgery
Patients undergoing cardiac surgery develop a marked postoperative systemic inflammatory response. Blood transfusion may contribute to disruption of homeostasis in these patients. We sought to evaluate the imp...
-
Article
Open AccessGlucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung
-
Article
Open AccessInterferon beta-1a for COVID-19: critical importance of the administration route
-
Article
Regulation of CD73 in the development of lower limb atherosclerosis
Atherosclerosis is an inflammatory process of the arterial wall. CD73 (also known as ecto-5′-nucleotidase) is a key regulator of cell signaling in response to inflammation and hypoxia, and may be important in ...
-
Article
Open AccessHypoxia-induced inflammation and purinergic signaling in cross clam** the human aorta
Open aortic surgery evokes a systemic inflammatory response and is associated with high morbidity and mortality. Purinergic signaling has been shown to be crucial for maintaining vascular integrity and attenu...
