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Article
Open AccessMacrophage mannose receptor CD206 targeting of fluoride-18 labeled mannosylated dextran: A validation study in mice
Aluminum fluoride-18-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated mannosylated dextran derivative (Al[18F]F-NOTA-D10CM) is a new tracer for PET imaging. We report here on in vitro and in vivo v...
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Article
Open AccessDetection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [68Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) can be imaged with positron emission tomography (PET), but existing PET radiopharmaceuticals have limited diagnostic accuracy. Vascular adhesion protein-1 (VAP-1) is an endothe...
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Article
Open AccessAerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study
Physical activity is essential in weight management, improves overall health, and mitigates obesity-related risk markers. Besides inducing changes in systemic metabolism, habitual exercise may improve gut’s mi...
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Article
Open AccessPolymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19
The use of glucocorticoids has given contradictory results for treating acute respiratory distress syndrome (ARDS). The use of intravenous Interferon beta (IFN β) for the treatment of ARDS was recently tested ...
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Article
Open AccessNewly identified form of phenotypic plasticity of cancer: immunogenic mimicry
Cancer plasticity is now a recognized new hallmark of cancer which is due to disturbances of cell differentiation programs. It is manifested not only in various forms like the best-known epithelial-mesenchymal...
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Article
Open AccessPancreatic cancer survival prediction via inflammatory serum markers
For prognostic evaluation of pancreatic ductal adenocarcinoma (PDAC), the only well-established serum marker is carbohydrate antigen CA19-9. To improve the accuracy of survival prediction, we tested the effica...
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Article
Open AccessCD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity
ATP and adenosine have emerged as important signaling molecules involved in vascular remodeling, retinal functioning and neurovascular coupling in the mammalian eye. However, little is known about the regulato...
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Article
Open AccessCirculating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to exa...
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Article
Open AccessVascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation
Although the development of hematopoietic stem cells (HSC) has been studied in great detail, their heterogeneity and relationships to different cell lineages remain incompletely understood. Moreover, the role ...
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Article
Open AccessRed blood cell transfusion induces abnormal HIF-1α response to cytokine storm after adult cardiac surgery
Patients undergoing cardiac surgery develop a marked postoperative systemic inflammatory response. Blood transfusion may contribute to disruption of homeostasis in these patients. We sought to evaluate the imp...
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Article
Open AccessA prognostic model for colorectal cancer based on CEA and a 48-multiplex serum biomarker panel
Mortality in colorectal cancer (CRC) remains high, resulting in 860,000 deaths annually. Carcinoembryonic antigen is widely used in clinics for CRC patient follow-up, despite carrying a limited prognostic valu...
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Article
Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity
The product of Aoc3 gene is known as vascular adhesion protein-1 (VAP-1), a glycoprotein contributing to leukocyte extravasation and exhibiting semicarbazide-sensitive amine oxidase activity (SSAO). Regarding the...
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Article
Open AccessPrognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer
Immune suppressing molecule CD73 is overexpressed in various cancers and associated with poor survival. Little is so far known about the predictive value of CD73 in pancreatic ductal adenocarcinoma (PDAC). The...
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Article
Open AccessEfficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis
Activated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor-β (FR-β), representing a promising target for the treatment of MS. Here, we both evaluated the efficacy of a n...
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Article
Open AccessImmunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer
Immune response against cancer has prognostic impact but its role in gastric cancer is poorly known. The aim of the study was to assess the prognostic significance of immune cell score (CD3+, CD8+), tumour imm...
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Article
Open AccessGlucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung
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Article
Lymphatic endothelial cells of the lymph node
The influx and efflux of cells and antigens to and from the draining lymph nodes largely take place through the subcapsular, cortical and medullary sinus systems. Recent analyses in mice and humans have reveal...
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Article
Open AccessNew tools to prevent cancer growth and spread: a ‘Clever’ approach
Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes and macrophages. Its role in cancer...
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Article
Open AccessInterferon beta-1a for COVID-19: critical importance of the administration route
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Histochemical Approach for Simultaneous Detection of Ectonucleotidase and Alkaline Phosphatase Activities in Tissues
Studies on pathophysiology and the therapeutic potential of extracellular ATP and other purines represent an important and rapidly evolving field. The integral response of the cell is determined by multiple fa...
