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Article
Open AccessSingle-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
Immunological control of residual leukemia cells is thought to occur in patients with chronic myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine kinase inhibitor (TKI) disco...
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Article
Open AccessUmbilical cord blood DNA methylation in children who later develop type 1 diabetes
Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated w...
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Article
Open AccessThe tumor and plasma cytokine profiles of renal cell carcinoma patients
Renal cell carcinoma (RCC) accounts for 90% of all renal cancers and is considered highly immunogenic. Although many studies have reported the circulating peripheral cytokine profiles, the signatures between t...
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Article
Open AccessEarly DNA methylation changes in children develo** beta cell autoimmunity at a young age
Type 1 diabetes is a chronic autoimmune disease of complex aetiology, including a potential role for epigenetic regulation. Previous epigenomic studies focused mainly on clinically diagnosed individuals. The a...
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Article
Open AccessCharacterization and non-parametric modeling of the develo** serum proteome during infancy and early childhood
Children develop rapidly during the first years of life, and understanding the sources and associated levels of variation in the serum proteome is important when using serum proteins as markers for childhood d...
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Article
Open AccessProbe-level estimation improves the detection of differential splicing in Affymetrix exon array studies
The recent advent of exon microarrays has made it possible to reveal differences in alternative splicing events on a global scale. We introduce a novel statistical procedure that takes full advantage of the pr...
