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Article
The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: a consensus report
A European Union (EU) directive on vitamins and minerals used as ingredients of food supplements with a nutritional or physiological effect (2002/46/EC) was introduced in 2003. Its implications for the use of ...
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Article
The effect of DXA scanning on clinical decision making by general practitioners: a randomized, prospective trial of direct access versus referral to a hospital consultant
The objective of the study was to assess the impact of direct access DXA scanning (DADS) upon GPs' management decisions in patients considered to be at risk of osteoporosis. It was designed as a randomized, pr...
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Article
Osteoarthritis: a problem of joint failure
Osteoarthritis can be viewed as the clinical and pathological outcome of a range of disorders that results in structural and functional failure of synovial joints. Osteoarthritis occurs when the dynamic equil...
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Chapter
Role of Mechanical Factors in the Aetiology, Pathogenesis and Progression of Osteoarthritis
Motion and mechanical stimulation play a critical role in the development of the skeleton and normal joints [1, 2]. Movement, loading and intermittent mechanical strain are also crucial for the maintenance of ...
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Chapter
Non-Steroidal Anti-Inflammatory Drugs and Infertility
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely self-administered for the relief of musculoskeletal pain and commonly prescribed for women of child-bearing age with inflammatory arthritis. Although t...
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Chapter
Congenital Chloride Losing Enteropathy Associated with Tophaceous Gouty Arthritis
Congenital chloride losing enteropathy (familial chloride diarrhoea, congenital chloridorrhea)(1) is a recessively inherited disorder which results from a defect in chloride/bicarbonate exchange in the ileum. ...
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Chapter and Conference Paper
Crystal-Associated Inflammation: Some Mechanisms of Cellular Activation
Acute inflammation in association with crystals of monosodium urate is thought to be mediated by the presence of polymorphonuclear leucocytes (PMN) both in acute gouty arthritis and in experimentally induced c...
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Article
Hypoxanthine-guanine phosphoribosyltransferase deficiency in three brothers with gout: Characterization of a variant, HPRTEdinburgh, having altered isoelectric point, increased thermal lability and normal levels of messenger RNA
Three brothers who developed acute gouty arthritis at ages 16, 20 and 26 years were found to have increased plasma urate. Erythrocyte hypoxanthine phosphoribosyltransferase (HPRT) activity was less than 1% of ...
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Chapter
Azapropazone in gout and hyperuricaemia
After 20 years of clinical use as a non-steroidal anti-inflammatory drug (NSAID) azapropazone is now well established as both a useful agent for treating attacks of acute gouty arthritis and as single agent in...
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Article
Total and peripheral bone mass in patients with psoriatic arthritis and rheumatoid arthritis
Psoriatic arthritis is thought to be associated with periarticular osteoporosis while rheumatoid arthritis may be associated with generalised as well as periarticular bone loss. To assess...
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Article
Distribution of an anti-DNA idiotype among autoantibodies in patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA)
Autoantibodies from patients with systemic lupus erythematosus, rheumatoid arthritis, or other connective tissue disorders were probed for the presence of a cross-reactive idiotype (AM Id) originally defined o...
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Article
Corticosteroids and bone
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Article
Third Eular Workshop on Rheumatology Research
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Article
Eular workshop on Rheumatology Research
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Chapter
The Macrophage—Origins, Functions and Role in the Rheumatic Diseases
Metchnikoff1 recognized the importance of the macrophage in host defence and in mounting inflammatory responses in the nineteenth century; indeed it formed the cornerstone for his cellular theory of immunity. A v...
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Chapter
Purine and Pyrimidine Nucleotide Concentrations in Cells with Decreased Hypoxanthine-Guanine-Phosphoribosyltransferase (HGPRT) Activity
Severe and partial deficiency of the enzyme Hypoxanthineguanine-phosphoribosyl-transferase (HGPRT) (EC.2.4.2.8.) is associated with accelerated rates of purine biosynthesis de novo, both in vivo (1,2,3) and in cu...
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Article
Rheological simulation of synovial fluid by a synthetic macromolecular solution
The flow characteristics of a series of potential synthetic synovial fluids have been examined. These were mainly solutions of polyvinyl pyrrolidone in water. The techniques leading to the production of a flui...
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Article
Studies on the nature and significance of macromolecular complexes in the rheology of synovial fluid from normal and diseased human joints
The rheological characteristics of synovial fluid have been examined with aWeissenberg Rheogoniometer.
