SpringerLink
Log in

Total and peripheral bone mass in patients with psoriatic arthritis and rheumatoid arthritis

  • Originals
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Summary

Psoriatic arthritis is thought to be associated with periarticular osteoporosis while rheumatoid arthritis may be associated with generalised as well as periarticular bone loss. To assess the extent of total and peripheral bone loss in these two diseases, total body calcium was measured by in vivo neutron activation analysis and peripheral bone mass was assessed by metacarpal indices in age-matched patients with psoriatic arthritis and rheumatoid arthritis treated with nonsteroidal anti-inflammatory drugs alone. In comparison with age and sex-matched normal controls, total and peripheral bone mass was normal in psoriatic arthritis. There were significant reductions in total (6.2% in men; 7.9% in women) and peripheral (10.9% in men; 12.8% in women) bone mass in patients with rheumatoid arthritis compared with controls. Peripheral bone mass was significantly correlated with the degree of radiographic damage in male and female patients with rheumatoid arthritis. The mean annual loss of total body calcium was insignificant in psoriatic arthritis (0.6% in men; 1.9% in women) but markedly greater in rheumatoid arthritis (4.4% in men; 2.7% in women). The data suggested that total and peripheral bone loss is greater in rheumatoid arthritis than psoriatic arthritis. Substantial reductions in peripheral bone mass in patients with rheumatoid arthritis not receiving corticosteroids may account in part for the small reductions in total bone mass.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wright, V. Psoriatic arthritis. A comparative radiographic study of rheumatoid arthritis and arthritis associated with psoriasis. Ann Rheum Dis 1961, 20, 123–132.

    Article  PubMed  CAS  Google Scholar 

  2. Sherman, M.S. Psoriatic arthritis. — Observations on the clinical, roentgenographic and pathological changes. J Bone Jt Surg 1952, 34A, 831–852.

    Google Scholar 

  3. Wright, V., Moll, J.M.H. Seronegative polyarthritis. Amsterdam; Elsevier North Holland Publishing Company, 1976.

    Google Scholar 

  4. Bywaters, E. The early radiological signs of rheumatoid arthritis. Bull Rheum Dis 1960, 11, 231–4.

    PubMed  CAS  Google Scholar 

  5. Genant, H.K. Radiology of rheumatic diseases. In: McCarty D.J., ed. Arthritis and Allied Conditions. New York: Lea Feabiger, 1979, 70–130.

    Google Scholar 

  6. Duncan, H., Frost, H.M., Villaneuva, A.R., Sigler, J.W. The osteoporosis of rheumatoid arthritis. Arthritis Rheum 1965, 8, 943–54.

    PubMed  CAS  Google Scholar 

  7. Kennedy, A.C., Lindsay, R. Bone involvement in rheumatoid arthritis. Clin Rheum Dis 1977, 3, 403–20.

    Google Scholar 

  8. Moll, J.M.H., Wright, V. Psoriatric arthritis. Semin Arthritis Rheum 1973, 3, 55–78.

    PubMed  CAS  Google Scholar 

  9. Kennedy, N.S.J., Eastell, R., Ferrington, C.M. et al. Total body neutron activation analysis of calcium: calibration and normalisation. Phys Med Biol 1982, 27, 697–707.

    PubMed  CAS  Google Scholar 

  10. Tothill, P., Nicoll, J., Kennedy, N.S.J., Smith, M.A., Reid, D.M., Nuki, G. The in-vivo precision of total body calcium determinations by neutron activation analysis. In: Osteoporosis. Christiansen, C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL. Eds. Denmark: Department of Clinical Chemistry, Glostrup Hospital, 1984, 217–8.

    Google Scholar 

  11. Dequeker, J. Quantitative radiology: Radiogrammetry of cortical bone. Br J Radiol 1976, 49, 912–20.

    Article  PubMed  CAS  Google Scholar 

  12. Reid, D.M., Smith, M.A., Kennedy, N.S.J., Tothill, P., Nuki, G. Comparison of metacarpal indices with total body calcium. Calcif Tiss Int 1983, 35s, A4, 16.

    Google Scholar 

  13. Steinbrocker, O., Traeger, C.H., Batterman, R.C. Therapeutic criteria in rheumatoid arthritis. J A M A 1948, 140, 659–62.

    Google Scholar 

  14. Skibsted Als, O., Gotfredsen, A., Christiansen, C. Relationship between local and total bone mineral in patients with rheumatoid arthritis and normal subjects. Clin Rheumatol 1983, 2, 265–71.

    PubMed  CAS  Google Scholar 

  15. Reid, D.M., Kennedy, N.S.J., Smith, M.A., Tothill, P., Nuki, G. Total body calcium in rheumatoid arthritis: effects of disease activity and corticosteroid treatment. Br Med J 1982, 285, 330–2.

    Article  CAS  Google Scholar 

  16. Bjelle, A.O., Nilsson, B.E. The relationship between radiological changes and osteoporosis of the hand in rheumatoid arthritis. Arthritis Rheum 1971, 14, 646–9.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rheumatic Diseases Unit, Northern General Hospital, University of Edinburgh, Edinburgh, UK

    D. M. Reid & G. Nuki

  2. Department of Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK

    D. M. Reid & G. Nuki

  3. Department of Medical Physics and Medical Engineering, University of Edinburgh, Edinburgh, UK

    N. S. J. Kennedy, J. Nicoll, M. A. Smith & P. Tothill

Authors
  1. D. M. Reid
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. S. J. Kennedy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Nicoll
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. A. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Tothill
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Nuki
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reid, D.M., Kennedy, N.S.J., Nicoll, J. et al. Total and peripheral bone mass in patients with psoriatic arthritis and rheumatoid arthritis. Clin Rheumatol 5, 372–378 (1986). https://doi.org/10.1007/BF02054256

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02054256

Key words

Search

Navigation