Abstract
Motion and mechanical stimulation play a critical role in the development of the skeleton and normal joints [1, 2]. Movement, loading and intermittent mechanical strain are also crucial for the maintenance of healthy articular cartilage, [3], bone mineral [4] and muscle [5]. Paradoxically mechanical factors also play an important role in the development and progression of osteoarthritis.
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References
O’Rahilly R, Gardner E (1978) The embryology of movable joints. In: Sokoloff L (Ed) The joints and synovial fluid. Vol 1 Academic press, New York pp 49–103
Solursh M (1986) Environmental regulation of limb chondrogenesis. In: Kuettner KE, Schleyerbach R, Hascall VC (Eds) Articular cartilage biochemistry. Raven Press, New York pp 145–161
Helminen HJ, Kiviranta I, Saamanen AM et al. (1991). In: Kuettner KE, Schleyerbach R, Peyron JG, Hascall VC (Eds) Articular cartilage and osteoarthritis. Raven Press, New York pp 501–510
Lanyon LE (1987) Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling. J Biomech 20: 1083–1093
Henriksson J, Hickner RC (1994) Training induced adaptations in skeletal muscle. In: Harries M, Williams C, Stanish WD, Michaeli LJ (Eds) Oxford Textbook of Sports Medicine. Oxford Medical Publications, Oxford pp 27–45
Kuettner K, Goldberg VM (Eds) (1995) Osteoarthritic disorders. American Academy of Orthopaedic Surgeons, Rosemont pp 21–25
Nuki G (Ed) (1980) The aetiopathogenesis of osteoarthrosis. Pitman Medical, London
Nuki G (1998) Osteoarthritis: a problem of joint failure (in press)
Brandt KD, Lohmander LS, Doherty M (1998) Pathogenesis of osteoarthritis. Introduction: the concept of osteoarthritis as failure of the diathrodial joint. In: Brandt KD, Lohmander LS, Doherty M (Eds) Osteoarthritis. Oxford University Press, Oxford pp 70–74
Mankin HJ, Brandt KD, Shulman LE (1986) Workshop on aetiopathogenesis of osteoarthritis: proceedings and recommendations. J Rheumatol 13: 1130–1160
Altman RD (1995) The classification of osteoarthritis. J Rheumatol 22 (Suppl 43): 42–43
Doherty M, Watt I, Dieppe PA (1983) Influence of primary generalised osteoarthritis on development of secondary osteoarthritis. Lancet 2: 8–11
Roos H, Adalberth T, Lohmander LS (1996) Osteoarthrosis after meniscectomy. Ann Rheum Dis 55: 692
Oliveria SA, Felson DT, Reed JI et al. (1995) Incidence of symptomatic hand, hip and knee osteoarthritis among patients in a health maintenance organisation. Arthritis Rheum 38: 1134–1141
Hardingham TE, Venn G, Bayliss MT (1991) Chondrocyte responses in cartilage and in experimental osteoarthritis. Brit J Rheumatol 30 (Suppl 1): 32–37
Roughley PJ, White RG, Magny MC et al. (1993) Non-proteoglycan forms of biglycan increase with age in human articular cartilage. Biochem J 295: 421–427
Holmes MW, Bayliss MT, Muir H (1988) Hyaluronic acid in human articular cartilage. Age-related changes in content and size. Biochem J 250: 433–441
Kempson GE (1975) Mechanical properties of articular cartilage and their relationship to matrix degradation and age. Ann Rheum Dis 32 (Suppl 2): 11–113
Roth V, Mow VC (1980) The intrinsic tensile behaviour of the matrix of bovine articular cartilage and its variation with age. J Bone Joint Surg 62 A: 1102–1117
Kempson GE, Muir H, Pollard C et al. (1973) The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans. Biochim Biophys Acta 297: 456–472
Wachtel E, Maroudas A, Schneiderman R (1995) Age related changes in collagen packing of human articular cartilage. Biochim Biophy Acta 1243: 239–243
Kirk JA, Ansell BM, Bywaters EGL (1967) The hypermobility syndrome. Ann Rheum Dis 26: 419–425
Bird HA, Tribe CR, Bacon PA (1978) Joint hypermobility leading to osteoarthrosis and chondrocalcinosis. Ann Rheum Dis 37: 203–211
Bridges AJ, Smith E, Reid J (1992) Joint hypermobility in adults referred to rheumatology clinics. Ann Rheum Dis 51: 793–796
Harper P, Nuki G (1980) Genetic factors in osteoarthrosis. In: Nuki G (Ed). The aetiopathogenesis of osteoarthrosis. Pitman Medical, London pp 184–201
Jonsson H, Valtysdottir ST, Kjartansson O et al. (1996) Hypermobility associated with osteoarthritis of the thumb base. A clinical and radiological subset of hand osteoarthritis. Ann Rheum Dis 55: 540–543
Wright V (1990) Post-traumatic osteoarthritis-a medico-legal minefield. Brit J Rheumatol 29: 424–478
Felson DT (1990) The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Seminars Arthritis Rheum 20: 42–50
Harris WH (1969) Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. J Bone Joint Surg 51A: 737–755
Jacobsen K (1977) Osteoarthrosis following insufficiency of the cruciate ligaments in man. Acta Orthopaedica Scand 48: 520–526
Tirgari M, Vaughan LC (1975) Arthritis of the canine stifle joint. Vet Rec 96: 394–399
Pond MJ, Nuki G (1973) Experimentally-induced osteoarthritis in the dog. Ann Rheum Dis 32: 387–388
Chantraine A (1985) Knee joint in soccer players: osteoarthritis and axis deviation. Med Sci Sports Exercise 17: 434–439
Roos H, Lindberg H, Gardsell P (1994) The prevalence of gonarthrosis in former soccer players and its relation to meniscectomy. Am J Sports Med 22: 219–222
Rall KL, McElroy GL, Keats TE (1964) A study of long-term effects of football injury to the knee. Mo Med 61: 435–438
Harris PA, Hart DJ, Jawad S et al. (1994) Risks of osteoarthritis associated with running: a radiological survey of ex-athletes. Arthritis Rheum 37: S369
Vingard E, Alfredsson L, Goldie I et al. (1993) Sports and osteoarthrosis of the hip. An epidemiological study. Am J Sports Med 21: 195–200
Paranen J, Ala-Ketola L, Peltokallio P et al. (1975) Running and primary osteoarthritis of the hip. Brit Med J 1: 424–425
Kujala VM, Kettunen J, Paananen H et al. (1995) Knee osteoarthritis in former runners, soccer players, weight lifters and shooters. Arthritis Rheum 38: 539–546
Spector TD, Harris PA, Hart DJ et al. (1996) Risks of osteoarthritis associated with long-term weight-bearing sports: a radiographic surgery of the hips and knees in female ex-athletes and population controls. Arthritis Rheum 39: 988–995
Buckwalter JA, Lane NE (1997) Athletics and osteoarthritis. Am J Sports Med 25: 873–881
Cooper C, MacAlindon T, Egger P et al. (1994) Occupational activity and osteoarthritis of the knee. Ann Rheum Dis 53: 90–93
Anderson JAD, Duthie JJR, Moody BP (1962) Social and economic effects of rheumatic diseases in a mining population. Ann Rheum Dis 21: 342–352
Partridge REH, Duthie JJR (1968) Rheumatism in dockers and civil servants. Ann Rheum Dis 27: 559–568
Vingard E, Alfredsson L, Goldie I et al. (1991) Occupation and osteoarthrosis of the hip and knee: a register based cohort study. Int J Epidemiol 20: 1025–1031
Croft P, Coggon D, Cruddas M et al. (1992) Osteoarthritis of the hip: an occupational disease in farmers. Brit Med J 304: 1269–1272
Anderson JJ, Felson DT (1988) Factors associated with osteoarthritis of the knee in the first national health and nutrition examination survey (HANES-1). Am J Epidemiol 128: 179–189
Felson DT, Hannan MT, Maimark A et al. (1991) Occupational physical demands, knee bending and knee osteoarthritis: results from the Framingham study. J Rheumatol 18: 1587–1592
Lawrence JS (1961) Rheumatism in cotton operatives. Br J Ind Med 18: 270–276
Hadler NM, Gillings DB, Imbus R et al. (1978) Hand structure and function in an industrial setting. Arthritis Rheum 21: 210–220
Felson DT, Chaisson CE (1997) Understanding the relationship between body weight and osteoarthritis. Bailliere’s Clin Rheumatol 11 (4): 671–681
MacAlinden T, Zhang Y, Hannan MT et al. (1996) Are risk factors for patellofemoral and tibiofemoral knee osteoarthritis different? J Rheumatol 23: 332–337
Cicuttini FM, Baker JR, Spector TD (1996) The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol 23: 1221–1226
Felson DT, Zhang Y, Hannan MT et al. (1997) Risk factors for incident radiographic osteoarthritis in the elderly: the Framingham study. Arthritis Rheum 40: 728–733
Hannan MT, Anderson JJ, Zhang Y et al. (1993) Bone mineral density and knee osteoarthritis in elderly men and women: the Framingham study. Arthritis Rheum 36: 1671–1680
Radin EL, Paul IL, Lovy M (1970) A comparison of the dynamic force transmitting properties of subchondral bone and articular cartilage. J Bone Joint Surg 52 A: 444–456
Finlay JB Repo RU (1978) Cartilage impact in-vitro: effect of bone and cement. J Biomechanics 11: 379–388
Redler I, Mow VC, Zimny MC et al. (1975) The ultrastructure and biomechanical significance of the tidemark of articular cartilage. Clin Orthopaedics and Related Research 112: 357–362
Radin EL, Rose RM (1986) Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthopaedics and Related Research 213: 34–40
Brown TD, Radin EL, Martin RB et al. (1984) Finite element studies of some juxta-articular stress changes due to localised subchondral stiffening. J Biomechanics 17: 11–24
Hoshino A, Wallace WA (1987) Impact absorbing properties of the human knee. J Bone Joint Surg 69B: 807–811
Foss MVL, Byers PD (1972) Bone density, osteoarthrosis of the hip and fracture of the upper end of the femur. Ann Rheum Dis 31: 259–264
Dequeker J (1985) The relationship between osteoporosis and osteoarthritis. Clinics in the Rheumatic Diseases 11: 271–296
Vertraeten A, Van Erman H, Haghebaert G et al. (1991) Osteoarthrosis retards the development of osteoporosis. Clin Orthopaedics and Related Research 264: 169–177
Pogrund H, Rutenberg M, Makin M et al. (1982) Osteoarthritis of the hip joint and osteoporosis: a radiological study in a random population sample in Jerusalem. Clin Orthopaedics and Related Research 164: 130–135
Murray RO (1965) The aetiology of primary osteoarthritis of the hip. Brit J Radiol 38: 810–824
Stulberg SD, Harris WH (1974) Acetabular dysplasia and development of osteoarthritis of the hip. In: Harris WH (Ed) The hip. Proceedings of the second open scientific meeting of the hip society. Mosby, St Louis pp 82–93
Cooperman DR, Wallenstein R, Stulbert SD (1983) Acetabular dysplasia in the adult. Clin Orthop 175: 79–85
Croft P, Cooper C, Wickham C et al. (1991) Osteoarthritis of the hip and acetabular dysplasia. Ann Rheum Dis 50: 308–310
Palotie A, Vaisanen P, Ott J et al. (1989) Predisposition to familial osteoarthritis linked to type II collagen gene. Lancet 1: 924–927
Knowlton RG, Katzenstein PL, Moskowitz RW et al. (1990) Genetic linkage of a polymorphism of the type II collagen gene (COL21A) to primary osteoarthritis associated with mild chondrodysplasia. New Eng J Med 322: 526–530
Jimenez SA, Williams CJ, Karasick D (1998) Hereditary osteoarthritis. In: Brandt KD, Doherty M, Lohmander LS (Eds) Osteoarthritis. Oxford University Press, Oxford pp 931–49
Jacenko O, Olsen BR (1995) Transgenic mouse models in studies of skeletal disorders. J Rheumatol 22 (Suppl 43): 39–41
McIntosh I, Abbott MH, Francomano CA (1995) Concentration of mutations causing Schmid metaphyseal chondrodysplasia in the c-terminal non-collagenous domain of type X collagen. Human mutation 5: 121–125
Briggs MD, Hoffman SMG, King LM et al. (1995) Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. Nature Genetics 10: 330–336
O’Connor BL, Palmoski MJ, Brandt KD (1985) Neurogenic acceleration of degenerative joint lesions. J Bone Joint Surg 67-A: 562–571
Barrett DS, Cobb AG, Bentley G (1991) Joint proprioception in normal, osteoarthritic and replaced knees. J Bone Joint Surg 73-B: 53–56
Radin EL, Yang KH, Reiger C et al. (1991) Relationship between lower limb dynamics and knee joint pain. J Orthop Res 9: 398–405
Urban JPG, Hall AC (1994) The effects of hydrostatic and osmotic pressures on chondrocyte metabolism. In: Mow VC, Guilak F, Tran-Son Tay R, Hochmuth RM (Eds) Cell mechanics and cellular engineering. Springer Verlag, New York pp 348–419
Mow VC, Ratcliffe A, Poole AR (1992) Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. Biomaterials 13: 67–97
Stockwell RA (1991) Cartilage failure in osteoarthritis: relevance of normal structure and function. A review. Clinical Anatomy 4: 161–191
Hodge WA, Fijan RS, Carlson KL et al. (1986) Contact pressures in the human hip joint measured in vivo. Proc Natl Acad Sci (USA) 83: 2879–2883
Armstrong CG, Bahrani AS, Gardner DL (1980) Changes in deformational behaviour of human hip cartilage with age. J Biomech Eng 102: 214–220
Parkkinen JJ, Ikonen J, Lammi MJ et al. (1993) Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. Arch Biochem Biophy 300: 458–465
Sah RL, Grodzinsky AJ, Plaas AHK et al. (1992) Effects of static and dynamic compression on matrix metabolism in cartilage explants. In: Kuettner K, Schleyerbach R, Peyron J, Hascall VC (Eds) Articular cartilage and osteoarthritis. Raven Press, New York pp 373–392
Hall AC, Urban JPG, Gehl GA (1991) The effects of hydrostatic pressure on matrix synthesis in articular cartilage. J Orthop Res 9: 1–10
Saamanen A-M, Tammi J, Jurvelin I et al. (1990) Proteoglycan alterations following immobilisation and remobilisation in the articular cartilage of young canine knee (stifle) joint. J Orthop Res 8: 863–873
Kiviranta I, Jurvelin J, Tammi M et al. (1987) Weightbearing controls glycosaminoglycan concentration and thickness of articular cartilage in knee joints of young Beagle dogs. Arthritis Rheum 30: 801–808
Veldhuijzen JP, Bourret LA, Rodan GA (1979) In vitro studies of the effect of intermittent compressive forces on cartilage cell proliferation. J Cell Physiol 98: 299–306
Wright MO, Stockwell RA, Nuki G (1992) Response of plasma membrane to applied hydrostatic pressure in chondrocytes and fibroblasts. Connect Tissue Res 28: 49–70
Wright MO, Jobanputra P, Bavington C, Salter DM, Nuki G (1996) Effects of intermittent pressure-induced strain on the electrophysiology of cultured human chondrocytes: evidence for the presence of stretch-activated ion channels. Clinical Science 90: 61–71
Wright MO, Jobanputra P, Bavington C, Salter DM, Nuki G (1995) Intracellular signal transduction pathways in human chondrocytes stimulated by intermittent pressurisation. J Bone Joint Surg 29-A: 88
Nuki G, Bavington C, Jobanputra P et al. (1994) Stretch-activated ion channels in human chondrocytes and proteoglycan synthesis following cyclical pressurisation of chondrocytes. Osteoarthritis and Cartilage 2: 533
Wright MO, Nishida K, Bavington C et al. (1997) Hyperpolarisation of cultured human chondrocytes following cyclical pressure-induced strain: evidence of a role for α5β1 integrin as a chondrocyte mechanoreceptor. J Orthopaed Res 15: 742–747
Millward-Sadler SJ, Wright MO, Nishida K et al. (1998) Integrin-regulated secretion of interleukin-4: a novel pathway of mechanotransduction in human articular chondrocytes. Submitted for publication
Lin H, Bavington C, Goldring MB et al. (1998) P38 MAP Kinase controls the accelerated proteoglycan synthesis that follows cyclical strain in immortalised human chondrocytes. Brit J Rheumatol 37(Suppl 1): 18
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Nuki, G. (1999). Role of Mechanical Factors in the Aetiology, Pathogenesis and Progression of Osteoarthritis. In: Osteoarthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60026-5_6
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DOI: https://doi.org/10.1007/978-3-642-60026-5_6
Publisher Name: Springer, Berlin, Heidelberg
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