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Open AccessFurther improvement of warming-equivalent emissions calculation
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A subterranean ant Acanthostichus Mayr, 1887 is revealed in Costa Rica
In this study, pinned insect specimens derived from Malaise traps in Costa Rica were identified using a collaborative process, resulting in a significant addition to our understanding of the range of a rare Ne...
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A review of new agents evaluated against pediatric acute lymphoblastic leukemia by the Pediatric Preclinical Testing Program
Acute lymphoblastic leukemia (ALL) in children exemplifies how multi-agent chemotherapy has improved the outcome for patients. Refinements in treatment protocols and improvements in supportive care for this mo...
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Open AccessLanicemine: a low-trap** NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
Ketamine, an N-methyl-D-aspartate receptor (NMDAR) channel blocker, has been found to induce rapid and robust antidepressant-like effects in rodent models and in treatment-refractory depressed patients. However, ...
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Oral alprazolam acutely increases nucleus accumbens perfusion
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Open AccessPerk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis
Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function ca...
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Open AccessInhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity
Although oligomeric β-amyloid (Aβ) has been suggested to have an important role in Alzheimer disease (AD), the mechanism(s) of how Aβ induces neuronal cell death has not been fully identified. The balance of pro-...
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Mass spectrometry of molecules and radicals in glow discharge plasma
The article represents a method and equipment developed for mass spectrometric analysis of plasma, that is, for measurement of concentration of atoms and molecules, and their fragments, including free radicals...
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Reactions of HBr+ ions in the 2Π i , v + quantum states with H2 and HBr molecules
The mechanisms and kinetics of low-temperature ion-molecular reactions between the Br+, HBr+, and DBr+ions and the HBr, DBr, H2, and D2 molecules were studied. The HBr+ (i,v +) and DBr+(i,
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Reference Work Entry In depth
Parallels Between Neurodevelopment and Neurodegeneration: A Case Study of Alzheimer's Disease
An accumulating body of evidence shows significant similarities between cellular processes involved in neurodegeneration and those involved in neurodevelopment. Most striking, in Alzheimer's disease, cell cycl...
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Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration
A dinucleotide deletion in human ubiquitin (Ub) B messenger RNA leads to formation of polyubiquitin (UbB)+1, which has been implicated in neuronal cell death in Alzheimer's and other neurodegenerative diseases...
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Causes of oxidative stress in Alzheimer disease
Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen...
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Pittosporum undulatum is a potential Australian host of Phytophthora ramorum
Pittosporum undulatum is a potential Australian host of Phytophthora ramorum, the causal agent of sudden oak death in California. It was susceptible and supported sporulation in zoospore inoculat...
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Oxidative stress mechanisms and potential therapeutics in Alzheimer disease
Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important phenomenon involved in these disor...
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Alzheimer’s disease: the impact of age-related changes in reproductive hormones
Differences in the prevalence and age of onset of Alzheimer disease (AD) in men and women, and observations that hormone replacement therapy (HRT) may prevent the development of AD, caused many to hypothesize ...
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The impact of PET scanning on management of paediatric oncology patients
Limited information is available on the use of positron emission tomography (PET) in paediatric oncology. The aim of this study was to review the impact of PET on the management of paediatric patients scanned ...
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Neurofilament proteins in neurodegenerative diseases
The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neu...
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TNF-α expression patterns as potential molecular biomarker for human skin cells exposed to vesicant chemical warfare agents: sulfur mustard (HD) and Lewisite (L)
Studies were conducted to examine the effect of two vesicant chemical warfare agents (VCWA), one of them an arsenical, on cytokine gene expression in normal human epidermal keratinocyte (NHEK) cells. We tested...
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Oxidative stress and predominant Aβ42(43) deposition in myopathies with rimmed vacuoles
This study was undertaken to determine the C terminus of amyloid β protein (Aβ), accumulated in vacuolated muscle fibers, and compare these findings to the level of oxidative stress. Eight patients with myopat...
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Two Methods for Modelling the Propagation of Terahertz Radiation in a Layered Structure
Modelling the interaction of terahertz(THz) radiation with biological tissueposes many interesting problems. THzradiation is neither obviously described byan electric field distribution or anensemble of photon...
