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Article
Toleranzinduktion gegen Nickel
Nickel ist das häufigste Kontaktallergen des Menschen. Dennoch waren bis vor kurzem viele Fragen insbesondere bezüglich der Toleranzmechanismen gegenüber Nickel nicht geklärt. Neben humanen Ex-vivo-, Intervent...
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Chapter
Allergic and autoimmune reactions to xenobiotics: how do they evolve?
Immune reactions to xenobiotics (i.e. drugs, metals, industrial and naturally occurring chemicals) can give rise to allergy and autoimmunity. These reactions are frequent and encompass a broad spectrum of diff...
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Chapter
Polymorphisms of the Xenobiotic-Metabolizing Enzymes CYP1A1 and NAT-2 in Systemic Sclerosis and Lupus Erythematosus
The etiology of systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) is still unknown. In several cases, however, xenobiotics (i.e. drugs and occupational agent...
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Article
Equilibrium binding constants and facile dissociation of novel serum albumin-dicyanoaurate(I) complexes
Dicyanoaurate(I), Au(CN)2 –, an important metabolite of chrysotherapy agents (anti-arthritic gold drugs), contains two tightly bound cyanide ligands which render it relatively unreactive toward ligand exchange r...
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Chapter and Conference Paper
Adverse Immune Reactions to Drugs (Gold, Procainamide) and Environmental Chemicals (Mercury, Platinum): The Role of Phagocytic Cells in Generating Immunogenic Metabolites
Adverse immune reactions to drugs, sometimes termed drug hypersensitivity reactions, account for a considerable proportion of all adverse drug reactions [32]. These reactions pose a difficult problem for the d...
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Article
Insights into the mechanism of gold action provided by immunotoxicology: biooxidation of gold(I) to gold(III) detected by sensitized T-cells
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Article
Immunotoxicology: suppressive and stimulatory effects of drugs and environmental chemicals on the immune system
The fundamental characteristic of the adaptive immune system which has evolved in the vertebrates is the ability to recognise, and subsequently destroy, “foreign”, and potentially harmful, antigens. The select...
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Chapter and Conference Paper
The Popliteal Lymphnode Assay (PLNA) in Rodents: A Simple Functional Test for Detecting Sensitizing Effects of Xenobiotics
Adverse immune reactions belong to the most frequent untoward side-effects of drugs. They consist of allergic and autoimmune reactions which cause impairment of patients’ health and, occasionally, are fatal. I...
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Article
Third Eular Workshop on Rheumatology Research
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Chapter
Autoimmune Disease Strongly Resembling Systemic Lupus Erythematosus (SLE) in F1 Mice Undergoing Graft-Versus-Host Reaction (GVHR)
The etiology and cellular pathogenesis of human SLE and of the spontaneously arising SLE-like diseases of mice are still poorly understood. Especially, the possible participation of T helper (TH) cells and, if th...
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Chapter
Induction of Either Acute or Chronic Graft-Versus-Host Disease Due to Genetic Differences Among Donor T Cells
The clinical and pathological alterations induced by GVHR vary from stimulatory phenomena, such as SLE-like autoantibody formation, hypergammaglobulinemia, and lymphoproliferation, to suppressive phenomena, su...
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Chapter
Lymphomagenesis and Autoimmunization Caused by Reactions of T-Lymphocytes to Incompatible Structures of the Major Histocompatibility Complex: A Concept of Pathogenesis
The classic animal model for induction of graft-versus-host reactions (GVHRs) [1] is the parent → F1 hybrid system (Fig. 1). A variety of different pathologic lesions can be induced in this system, as has recentl...
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Article
Graft-versus-host reaction: a pathogenetic principle for the development of drug allergy, autoimmunity, and malignant lymphoma in non-chimeric individuals. Hypothesis
It is proposed that the same diseases as those induced by the graftversus-host reaction (GVHR) will arise in nonchimeric individuals, if structures of the major histocompatibility complex (MHC) on lymphocytes are...
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Chapter
Quantitative Serum Immunoglobulin Determinations in Active Chronic Hepatitis and Idiopathic Cirrhosis
A substantial increase in the serum gamma globulins is commonly observed in many types of chronic inflammatory diseases of the liver, and it is associated with an increased turnover rate (Popper and Schaffner;...
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Chapter
Quantitative Serum Immunoglobulin Determinations in Active Chronic Hepatitis and Idiopathic Cirrhosis
A substantial increase in the serum gamma globulins is commonly observed in many types of chronic inflammatory diseases of the liver, and it is associated with an increased turnover rate (Popper and Schaffner;...
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Article
Quantitative Immunglobulin-Bestimmungen im Serum bei entzündlichen Leberkrankheiten
Bei 66 Patienten mit chronisch entzündlichen Lebererkrankungen, 25 Patienten mit extra- oder intrahepatischen Gallenwegserkrankungen sowie bei 101 Patienten mit verschiedenen Erkrankungen wurden die Serumkonze...
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Article
Quantitative Immunglobulin-Bestimmungen im Serum bei entzündlichen Leberkrankheiten
Mit der einfachen radialen Immundiffusionsmethode wurden die Serumkonzentrationen von IgG, IgA und IgM bei 100 bzw. 150 Normalpersonen bestimmt. Bei 20 Personen mit akuter Hepatitis fanden wir in der ersten Wo...
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Chapter and Conference Paper
Quantitative Immunglobulinbestimmungen im Serum als Parameter der Entzündungsreaktion bei chronisch entzündlichen Leberkrankheiten
Nach POPPER [11] erlaubt von allen Serumuntersuchungen allein die Messung der Gamma-Globuline (= Immunglobuline = Ig) einen direkten Rückschluß auf die mesenchymale Entzündungsaktivität in einer erkrankten Leb...
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Article
Differenzierung der Hyper-γ-Globulinämie bei entzündlichen Lebererkrankungen
Alkoholische Lebercirrhosen und aktive chronische Hepatitiden unterscheiden sich hinsichtlich der absoluten Serumkonzentrationen von IgA und IgG. Ausdruck dieser Veränderungen ist der charakteristische Wert ei...
