89 Result(s)

Article

In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization

In postmenopausal osteoporotic women and up to 3 years of treatment with strontium ranelate, strontium was present only in recently deposited bone tissue resulting from formation activity during the period of ...

G. Boivin, D. Farlay, M. T. Khebbab, X. Jaurand, P. D. Delmas… in Osteoporosis International (2010)

Article

Influence of remodeling on the mineralization of bone tissue

G. Boivin, D. Farlay, Y. Bala, A. Doublier, P. J. Meunier… in Osteoporosis International (2009)

Article

Bone histomorphometry and bone quality

D. W. Dempster, J. E. Compston, P. J. Meunier in Osteoporosis International (2009)

Article

Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis

Strontium ranelate reduces the risk of fracture in post-menopausal osteoporotic women with prevalent fractures for whom quality of life is severely impaired. The SOTI study, which used the SF-36® questionnaire...

P. Marquis, C. Roux, C. de la Loge, M. Diaz-Curiel… in Osteoporosis International (2008)

Article

Combining clinical factors and quantitative ultrasound improves the detection of women both at low and high risk for hip fracture

We hypothesized that combining clinical risk factors (CRF) with the heel stiffness index (SI) measured via quantitative ultrasound (QUS) would improve the detection of women both at low and high risk for hip f...

C. Durosier, D. Hans, M. A. Krieg, C. Ruffieux, J. Cornuz… in Osteoporosis International (2007)

Article

Zoledronic acid efficacy and safety over five years in postmenopausal osteoporosis

In a 5-year study involving 119 postmenopausal women, zoledronic acid 4 mg given once-yearly for 2, 3 or 5 years was well tolerated with no evidence of excessive bone turnover reduction or any safety signals. ...

J. P. Devogelaer, J. P. Brown, P. Burckhardt, P. J. Meunier… in Osteoporosis International (2007)

Article

Which screening strategy using BMD measurements would be most cost effective for hip fracture prevention in elderly women? A decision analysis based on a Markov model

Hip fractures are responsible for excessive mortality, decreasing the 5-year survival rate by about 20%. From an economic perspective, they represent a major source of expense, with direct costs in hospitaliza...

A. M. Schott, C. Ganne, D. Hans, G. Monnier, R. Gauchoux… in Osteoporosis International (2007)

Article

Estimation of direct unit costs associated with non-vertebral osteoporotic fractures in five European countries

The objective of this study was to estimate the unit costs of non-vertebral osteoporotic fractures in five European countries based on the results of the SOTI and TROPOS clinical trials in postmenopausal osteo...

S. Bouee, A. Lafuma, F. Fagnani, P. J. Meunier… in Rheumatology International (2006)

Article

Addressing the Musculoskeletal Components of Fracture Risk with Calcium and Vitamin D: A Review of the Evidence

Osteoporotic fractures are an extremely common and serious health problem in the elderly. This article presents the rationale for calcium and vitamin D supplementation in the prevention and treatment of osteop...

S. Boonen, H. A. Bischoff-Ferrari, C. Cooper, P. Lips… in Calcified Tissue International (2006)

Article

Structural determinants of hip fracture in elderly women: re-analysis of the data from the EPIDOS study

Hip fracture is the most disastrous osteoporotic fracture, characterized by high mortality, morbidity and institutionalization for the patient and by high economic costs for the health care system. The morphol...

P. Szulc, F. Duboeuf, A. M. Schott, P. Dargent-Molina… in Osteoporosis International (2006)

Article

Body mass index as a predictor of fracture risk: A meta-analysis

Low body mass index (BMI) is a well-documented risk factor for future fracture. The aim of this study was to quantify this effect and to explore the association of BMI with fracture risk in relation to age, ge...

C. De Laet, J. A. Kanis, A. Odén, H. Johanson, O. Johnell… in Osteoporosis International (2005)

Article

Expression of PPARγ and β/δ in Human Primary Osteoblastic Cells: Influence of Polyunsaturated Fatty Acids

As previously reported, the age-related association between bone loss and increased marrow adipose volume may involve inhibitory effects of polyunsaturated fatty acids (PUFAs) potentially released by medullary...

A. C. Maurin, P. M. Chavassieux, P. J. Meunier in Calcified Tissue International (2005)

Article

Risk factors for hip fracture in women with high BMD: EPIDOS study

Hip fractures are common among older women. At the present time, major efforts are being made to identify women with low bone mineral density (BMD). However, more than half of hip fractures occur in women who ...

J. A. Robbins, A. M. Schott, P. Garnero, P. D. Delmas… in Osteoporosis International (2005)

Article

The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: a consensus report

A European Union (EU) directive on vitamins and minerals used as ingredients of food supplements with a nutritional or physiological effect (2002/46/EC) was introduced in 2003. Its implications for the use of ...

S. Boonen, R. Rizzoli, P. J. Meunier, M. Stone, G. Nuki… in Osteoporosis International (2004)

Article

Histomorphometric evaluation of daily and intermittent oral ibandronate in women with postmenopausal osteoporosis: results from the BONE study

The bisphosphonate ibandronate, administered either daily or intermittently with an extended between-dose interval of >2 months, has been shown to reduce significantly the incidence of vertebral fractures, to ...

R. R. Recker, R. S. Weinstein, C. H. Chesnut III… in Osteoporosis International (2004)

Article

Should age influence the choice of quantitative bone assessment technique in elderly women? The EPIDOS study

In a prospective cohort of 7,598 women aged 75 and over, we analyzed the effect of age on the ability of femoral neck bone mineral density (BMD) and of ultrasound (BUA and SOS) of the calcaneus to predict hip ...

A. M. Schott, B. Kassaï Koupaï, D. Hans, P. Dargent-Molina… in Osteoporosis International (2004)

Article

The mineralization of bone tissue: a forgotten dimension in osteoporosis research

Osteoporosis treatment should not only prevent the loss of bone tissue, not interfere with apatite and avoid bone mineral changes at the crystal level, but should also increase the mechanical resistance of bon...

G. Boivin, P. J. Meunier in Osteoporosis International (2003)

Article

Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis

The phase 3 program for strontium ranelate, a new oral agent in the treatment of women with postmenopausal osteoporosis, was aimed to assess the efficacy and safety of the daily oral dose of 2 g. This program ...

P. J. Meunier, J. Y. Reginster in Osteoporosis International (2003)

Article

Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies

The aim of the PREVOS study (PREVention Of early postmenopausal bone loss by Strontium ranelate) and the STRATOS study (STRontium Administration for Treatment of OSteoporosis) was to determine the minimum dose...

J. Y. Reginster, P. J. Meunier in Osteoporosis International (2003)