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  1. No Access

    Chapter and Conference Paper

    Precursor B Cells from Pax-5-deficient mice — Stem Cells for Macrophages, Granulocytes, Osteoclasts, Dendritic Cells, Natural Killer Cells, Thymocytes and T Cells

    At least three major cell differentiation lineages cooperate to build the system of lymphoid organs, each one derived from a separate stem cell. Hematopoietic stem cells give rise to T-lymphoid cells in the th...

    A. G. Rolink, F. Melchers in Lymphoid Organogenesis (2000)

  2. No Access

    Chapter and Conference Paper

    The Cluster of ABCD Chemokines which Organizes T Cell-Dependent B Cell Responses

    The ordered migration and cooperation of many different lineages of hematopoietic cells is a key requirement for the development and the responses of cells of the immune system and during an immune response. T...

    C. Schaniel, F. Melchers, A. G. Rolink in Lymphoid Organogenesis (2000)

  3. No Access

    Chapter and Conference Paper

    A Novel CC Chemokine ABCD-1, Produced by Dendritic Cells and Activated B Cells, Exclusively Attracts Activated T Lymphocytes

    Cells of the immune system can migrate as single cells through blood and lymph and can organize themselves to form specific areas in primary and secondary lymphoid organs. It has become evident that chemokines...

    C. Schaniel, F. Sallusto, P. Sideras, F. Melchers… in Mechanisms of B Cell Neoplasia 1998 (1999)

  4. No Access

    Chapter and Conference Paper

    The Transition from Immature to Mature B Cells

    The small pre-B II cells, such as those that can be found in the bone marrow, form the direct precursor pool of immature B cells that first express IgM at their surface. Experiments by Osmond and his colleague...

    A. G. Rolink, F. Melchers, J. Andersson in Mechanisms of B Cell Neoplasia 1998 (1999)

  5. No Access

    Chapter and Conference Paper

    Fetal Liver Organ Cultures as a Tool to Study Selection Processes During B Cell Development

    Recent studies concerning B cell development in the mouse embryo have indicated that the first cells committed to the B cell lineage arise in the para-aortic splanchnopleura at a time prior to the hematopoieti...

    R. Ceredig, A. G. Rolink, F. Melchers, J. Andersson in Mechanisms of B Cell Neoplasia 1998 (1999)

  6. No Access

    Chapter and Conference Paper

    The Formation and Selection of Cells Expressing PreB Cell Receptors and B Cell Receptors

    The repertoires of B cell receptor (Ig)-expressing B cells are generated during B cell development in a stepwise fashion (Tonegawa 1983). First, DH segments are rearranged to JH segments on the H chain locus at t...

    E. ten Boekel, T. Yamagami, J. Andersson… in Mechanisms of B Cell Neoplasia 1998 (1999)

  7. No Access

    Chapter and Conference Paper

    Human Macrophage-Derived Chemokine (MDC) is Strongly Expressed Following Activation of both Normal and Malignant Precursor and Mature B Cells

    Chemokines are a rapidly expanding group of secreted molecules that selectively control the migration and homing of leukocytes to different sites of inflammation and immune responses [1, 2]. They are believed ...

    P. Ghia, C. Schaniel, A.G Rolink, L. M. Nadler… in Mechanisms of B Cell Neoplasia 1998 (1999)

  8. No Access

    Article

    Third Eular Workshop on Rheumatology Research

    E. Gleichmann, F. M. van Rappard-van der Veen, A. G. Rolink… in Clinical Rheumatology (1983)

  9. No Access

    Chapter

    Autoimmune Disease Strongly Resembling Systemic Lupus Erythematosus (SLE) in F1 Mice Undergoing Graft-Versus-Host Reaction (GVHR)

    The etiology and cellular pathogenesis of human SLE and of the spontaneously arising SLE-like diseases of mice are still poorly understood. Especially, the possible participation of T helper (TH) cells and, if th...

    F. M. van der Veen, A. G. Rolink, E. Gleichmann in In Vivo Immunology (1982)