14 Result(s)

Article

Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-m...

P Jaako, S Debnath, K Olsson, Y Zhang, J Flygare, M S Lindström, D Bryder… in Leukemia (2015)

Article

TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

Members of the TALE (three-amino-acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage...

A Willer, J S Jakobsen, E Ohlsson, N Rapin, J Waage, M Billing, L Bullinger… in Leukemia (2015)

Article

SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q-myelodysplastic syndrome

K Siva, P Jaako, K Miharada, E Rörby, M Ehinger, G Karlsson, S Karlsson in Leukemia (2012)

Article

The role of Smad signaling in hematopoiesis and translational hematology

Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Histor...

U Blank, S Karlsson in Leukemia (2011)

Article

Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications

The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; how...

F J T Staal, C Baum, C Cowan, E Dzierzak, S Hacein-Bey-Abina, S Karlsson… in Leukemia (2011)

Article

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

PIM1 is a constitutively active serine/threonine kinase regulated by cytokines, growth factors and hormones. It has been implicated in the control of cell cycle progression and apoptosis and its overexpression...

V Iadevaia, S Caldarola, L Biondini, A Gismondi, S Karlsson, I Dianzani… in Oncogene (2010)

Article

TGF-β-mediated activation of RhoA signalling is required for efficient ^V12HaRas and ^V600EBRAF transformation

Transforming growth factor β-1 (TGF-β) acts as both a tumour suppressor and a tumour promoter in a context-dependent manner. The tumour-promoting activities of TGF-β are likely to result from a combination of ...

Y M Fleming, G J Ferguson, L C Spender, J Larsson, S Karlsson, B W Ozanne… in Oncogene (2009)

Article

Development of gene therapy for hematopoietic stem cells using lentiviral vectors

Lentiviral vectors are promising tools for the development of gene therapy since they can transduce both quiescent and dividing target cells. Lentiviral vectors may be particularly promising gene delivery tool...

N-B Woods, A Ooka, S Karlsson in Leukemia (2002)

Chapter and Conference Paper

Ultrasound, X-ray, and CT pelvimetry compared

Transabdominal pelvic inlet diameter and transverse mid-pelvic diameter measurements obtained with ultrasound and conventional X-ray pelvimetry were compared with those of digital radiography (computerized tom...

P.-H. Persson, S. Karlsson, B.-M. Weldner in Problems of the Pelvic Passageway (1987)