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  1. No Access

    Article

    Induction of the 5S RNP–Mdm2–p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia

    Mutations resulting in constitutive activation of signaling pathways that regulate ribosome biogenesis are among the most common genetic events in acute myeloid leukemia (AML). However, whether ribosome biogen...

    P Jaako, A Ugale, M Wahlestedt, T Velasco-Hernandez, J Cammenga, M S Lindström… in Leukemia (2017)

  2. No Access

    Article

    Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

    Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-m...

    P Jaako, S Debnath, K Olsson, Y Zhang, J Flygare, M S Lindström, D Bryder… in Leukemia (2015)

  3. Article

    Open Access

    PROX1 is a predictor of survival for gliomas WHO grade II

    The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers ...

    T Elsir, M Qu, S G Berntsson, A Orrego, T Olofsson… in British Journal of Cancer (2011)

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