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Article
The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia
C/EBPα (p42 and p30 isoforms) is commonly dysregulated in cancer via the action of oncogenes, and specifically in acute myeloid leukaemia (AML) by mutation. Elevated TRIB2 leads to the degradation of C/EBPα p4...
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Article
The multifaceted functions of C/EBPα in normal and malignant haematopoiesis
The process of blood formation, haematopoiesis, depends upon a small number of haematopoietic stem cells (HSCs) that reside in the bone marrow. Differentiation of HSCs is characterised by decreased expression ...
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Article
TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia
Members of the TALE (three-amino-acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage...
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Article
Potential impact of agroforestry on soil nutrient balances at the farm scale in the East African Highlands
There is much current interest in the potential role of agroforestry in the mitigation of nutrient depletion in Sub-Saharan Africa. Using data from farm surveys and trials, a static model of N and P flows was ...
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Article
Über Furfurol and Diastase in erhitztem Honig