15 Result(s)

Article

TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

Members of the TALE (three-amino-acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage...

A Willer, J S Jakobsen, E Ohlsson, N Rapin, J Waage, M Billing, L Bullinger… in Leukemia (2015)

Article

Patients with malignant hematological disorders treated on a palliative care unit: prognostic impact of clinical factors

A reliable estimation of prognosis in patients receiving palliative care is desirable in order to facilitate clinical decision finding. For patients with advanced hematological malignancies, only few data are ...

M. Kripp, A. Willer, C. Schmidt, L. R. Pilz, D. Gencer… in Annals of Hematology (2014)

Article

A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia

Chromosomal translocations of transcription factors generating fusion proteins with aberrant transcriptional activity are common in acute leukemia. In acute promyelocytic leukemia (APL), the promyelocytic leuk...

T T Marstrand, R Borup, A Willer, N Borregaard, A Sandelin, B T Porse… in Leukemia (2010)

Article

Auer rod-like inclusions in multiple myeloma

We report a case of IgA multiple myeloma, in which the plasma cells showed multiple azurophilic, Auer rod-like intracytoplasmic inclusions in May-Grünwald-Giemsa-stained marrow smears. Cytochemical stainings ...

G. Metzgeroth, W. Back, O. Maywald, M. Schatz, A. Willer… in Annals of Hematology (2003)

Article

Alterations of the cyclin D1/pRb/p16^INK4A pathway in multiple myeloma

The retinoblastoma protein (pRb), p16^INK4A, D-type cyclins, and their partners cyclin-dependent kinase (CDK) 4 and 6 constitute a G₁ regulatory pathway commonly targeted in tumorigenesis. Several malignancies sho...

A Krämer, B Schultheis, J Bergmann, A Willer, U Hegenbart, AD Ho, H Goldschmidt… in Leukemia (2002)

Article

Frequent polymorphism in BCR exon b2 identified in BCR-ABL positive and negative individuals using fluorescent hybridization probes

Recently, a polymorphic base in exon 13 of the BCR gene (exon b2 of the major breakpoint cluster region) has been identified in the eighth position before the junctional region of BCR-ABL cDNA. Cytosine replac...

S Saußele, A Weißer, MC Müller, M Emig, PLa Rosée, P Paschka, C Kuhn, A Willer… in Leukemia (2000)

Article

Analysis of p73 and p53 gene deletions in multiple myeloma

Recently, p73, a protein with structural and functional similarities to p53, an extensively studied tumor suppressor gene, has been cloned. After being mapped to the chromosomal region 1p35–1p36, it has been p...

B Schultheis, A Krämer, A Willer, U Hegenbart, H Goldschmidt, R Hehlmann in Leukemia (1999)

Article

Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR

We sought to establish a rapid and reliable RT-PCR approach for detection and quantification of BCR-ABL fusion transcripts using the LightCycler technology. This device combines rapid thermocycling with online...

M Emig, S Saußele, H Wittor, A Weißer, A Reiter, A Willer, U Berger, R Hehlmann… in Leukemia (1999)

Article

Intracellular expression of CD61 precedes surface expression

 We report a case of acute myeloid leukemia which we have classified as acute megakaryoblastic leukemia because of intracytoplasmic expression of CD61. Light microscopy demonstrated agranular blasts which, by ...

G. Käfer, A. Willer, W.-D. Ludwig, A. Krämer, R. Hehlmann… in Annals of Hematology (1999)

Article

Cyclin A1 is predominantly expressed in hematological malignancies with myeloid differentiation

Cyclin A is a cell cycle regulatory protein that functions in mitotic and S phase control in mammalian cells. However, in contrast to other G₁ phase regulatory proteins, such as cyclin D, retinoblastoma protein a...

A Krämer, A Hochhaus, S Saußele, A Reichert, A Willer, R Hehlmann in Leukemia (1998)

Article

XIX Symposium of the International Association for Comparative Research on Leukemia and Related Diseases

A. Hochhaus, U. Berger, A. Krämer, A. Reiter… in Journal of Cancer Research and Clinical On… (1998)

Article

Expression of interferon regulatory factor (IRF) genes and response to interferon-α in chronic myeloid leukaemia

Interferon regulatory factors (IRF) 1 and 2 are DNA-binding proteins which control interferon (IFN) gene expression. IRF1 functions as an activator for IFN and IFN-inducible genes, whereas IRF2 represses the a...

A Hochhaus, XH Yan, A Willer, R Hehlmann, MY Gordon, JM Goldman, JV Melo in Leukemia (1997)