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  1. No Access

    Article

    MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment

    Translocations involving the mixed lineage leukemia-1 are recurrent events in acute leukemia and associate with lymphoid (ALL), myeloid (AML) or mixed lineage (MLL) subtypes. Despite an association with ALL in...

    A Ugale, P Säwén, M Dudenhöffer-Pfeifer, M Wahlestedt, G L Norddahl, D Bryder in Oncogene (2017)

  2. No Access

    Article

    Induction of the 5S RNP–Mdm2–p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia

    Mutations resulting in constitutive activation of signaling pathways that regulate ribosome biogenesis are among the most common genetic events in acute myeloid leukemia (AML). However, whether ribosome biogen...

    P Jaako, A Ugale, M Wahlestedt, T Velasco-Hernandez, J Cammenga, M S Lindström… in Leukemia (2017)

  3. No Access

    Article

    Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

    Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-m...

    P Jaako, S Debnath, K Olsson, Y Zhang, J Flygare, M S Lindström, D Bryder… in Leukemia (2015)

  4. Article

    Open Access

    SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function

    Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). Ho...

    N Hansen, H Ågerstam, M Wahlestedt, N Landberg, M Askmyr, M Ehinger, M Rissler… in Leukemia (2013)

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  5. No Access

    Article

    Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence

    Somatic stem cells are ultimately responsible for mediating appropriate organ homeostasis and have therefore been proposed to represent a cellular origin of the ageing process—a state often characterized by in...

    J L Attema, C J H Pronk, G L Norddahl, J M Nygren, D Bryder in Oncogene (2009)