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  1. Article

    Open Access

    Discrete roles of canonical and non-canonical Wnt signaling in hematopoiesis and lymphopoiesis

    The mechanisms that regulate proliferation, fate decisions and differentiation of hematopoietic stem cells (HSC) and thymic stem cells are highly complex. Several signaling pathways including Wnt signaling hav...

    F Famili, B A E Naber, S Vloemans, E F E de Haas, M M Tiemessen… in Cell Death & Disease (2015)

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  2. Article

    Open Access

    Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia

    WNT signaling has been implicated in the regulation of hematopoietic stem cells and plays an important role during T-cell development in thymus. Here we investigated WNT pathway activation in childhood T-cell ...

    O H Ng, Y Erbilgin, S Firtina, T Celkan, Z Karakas, G Aydogan… in Blood Cancer Journal (2014)

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  3. No Access

    Article

    Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

    A strict balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is required in order to maintain homeostasis, as well as to efficiently respond to injury and infections. Numbers an...

    T C Luis, M Ichii, M H Brugman, P Kincade, F J T Staal in Leukemia (2012)

  4. Article

    Signal transduction pathways regulating hematopoietic stem cell biology: Introduction to a series of Spotlight Reviews

    T C Luis, N M-B Killmann, F J T Staal in Leukemia (2012)

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  5. No Access

    Article

    Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer

    Severe combined immunodeficiency (SCID) patients with an inactivating mutation in recombination activation gene 1 (RAG1) lack B and T cells due to the inability to rearrange immunoglobulin (Ig) and T-cell recepto...

    K Pike-Overzet, M Rodijk, Y-Y Ng, M R M Baert, C Lagresle-Peyrou, A Schambach… in Leukemia (2011)

  6. No Access

    Article

    Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications

    The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; how...

    F J T Staal, C Baum, C Cowan, E Dzierzak, S Hacein-Bey-Abina, S Karlsson… in Leukemia (2011)

  7. No Access

    Article

    Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK

    X-linked agammaglobulinemia (XLA) is the most common primary immunodeficiency (PID) in man and caused by mutations in the Bruton’s tyrosine kinase (BTK) gene. XLA is characterized by a B-cell differentiation arre...

    Y Y Ng, M R M Baert, K Pike-Overzet, M Rodijk, M H Brugman, A Schambach, C Baum… in Leukemia (2010)

  8. No Access

    Article

    Genome-wide expression analysis of paired diagnosis–relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phenotype

    Almost a quarter of pediatric patients with acute lymphoblastic leukemia (ALL) suffer from relapses. The biological mechanisms underlying therapy response and development of relapses have remained unclear. In ...

    F J T Staal, D de Ridder, T Szczepanski, T Schonewille, E C E van der Linden… in Leukemia (2010)

  9. No Access

    Article

    Flow cytometric immunobead assay for the detection of BCR–ABL fusion proteins in leukemia patients

    BCR–ABL fusion proteins show increased signaling through their ABL tyrosine kinase domain, which can be blocked by specific inhibitors, thereby providing effective treatment. This makes detection of BCR–ABL aberr...

    F Weerkamp, E Dekking, Y Y Ng, V H J van der Velden, H Wai, S Böttcher… in Leukemia (2009)

  10. No Access

    Article

    Sola dosis facit venenum. Leukemia in gene therapy trials: a question of vectors, inserts and dosage?

    In clinical gene therapy trials for X-linked severe combined immunodeficiency, the development of leukemia has come up as a severe adverse effect. In all five cases, T-cell acute lymphoblastic leukemia (T-ALL)...

    F J T Staal, K Pike-Overzet, Y Y Ng, J J M van Dongen in Leukemia (2008)

  11. No Access

    Article

    Ectopic retroviral expression of LMO2, but not IL2Rγ, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy

    The occurrence of leukemia in a gene therapy trial for SCID-X1 has highlighted insertional mutagenesis as an adverse effect. Although retroviral integration near the T-cell acute lymphoblastic leukemia (T-ALL)...

    K Pike-Overzet, D de Ridder, F Weerkamp, M R M Baert, M M A Verstegen… in Leukemia (2007)

  12. No Access

    Article

    T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34+CD38−CD7+ common lymphoid progenitors expressing lymphoid-specific genes

    Hematopoietic stem cells in the bone marrow (BM) give rise to all blood cells. According to the classic model of hematopoiesis, the differentiation paths leading to the myeloid and lymphoid lineages segregate ...

    I Hoebeke, M De Smedt, F Stolz, K Pike-Overzet, F J T Staal, J Plum, G Leclercq in Leukemia (2007)

  13. No Access

    Article

    Identification of Notch target genes in uncommitted T-cell progenitors: no direct induction of a T-cell specific gene program

    Deregulated Notch signaling occurs in the majority of human T-ALL. During normal lymphoid development, activation of the Notch signaling pathway poses a T-cell fate on hematopoietic progenitors. However, the t...

    F Weerkamp, T C Luis, B A E Naber, E E L Koster, L Jeannotte, J J M van Dongen… in Leukemia (2006)

  14. No Access

    Article

    Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networks

    A plethora of studies have documented that gene expression profiling using DNA microarrays for various types of hematological malignancies provides novel information, which may have diagnostic and prognostic i...

    F J T Staal, G Cario, G Cazzaniga, T Haferlach, M Heuser, W-K Hofmann, K Mills… in Leukemia (2006)

  15. No Access

    Article

    Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia

    Many acute lymphoblastic leukemias can be considered as malignant counterparts of cells in the various stages of normal lymphoid development in bone marrow and thymus. T-cell development in the thymus is an or...

    F Weerkamp, J J M van Dongen, F J T Staal in Leukemia (2006)

  16. No Access

    Article

    Purity for clarity: the need for purification of tumor cells in DNA microarray studies

    It is now well established that gene expression profiling using DNA microarrays can provide novel information about various types of hematological malignancies, which may lead to identification of novel diagno...

    D de Ridder, C E van der Linden, T Schonewille, W A Dik, M J T Reinders… in Leukemia (2005)

  17. Article

    Erratum: DNA microarrays for comparison of gene expression profiles between diagnosis and relapse in precursor-B acute lymphoblastic leukemia: choice of technique and purification influence the identification of potential diagnostic markers

    Correction to: Leukemia (2003) 17, 1324–1332. doi:10.1038/sj.leu.2402974 The authors would like to remark that, due to editorial changes in the above article, some references were accidentally switched. Refere...

    F J T Staal, M van der Burg, L F A Wessels, B H Barendregt, M R M Baert… in Leukemia (2004)

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  18. No Access

    Article

    DNA microarrays for comparison of gene expression profiles between diagnosis and relapse in precursor-B acute lymphoblastic leukemia: choice of technique and purification influence the identification of potential diagnostic markers

    Microarrays for gene expression profiling are rapidly becoming important research tools for the identification of novel markers, for example, for novel classification of leukemias and lymphomas. Here, we revie...

    F J T Staal, M van der Burg, L F A Wessels, B H Barendregt, M R M Baert… in Leukemia (2003)

  19. No Access

    Article

    Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development

    Class I homeobox (HOX) genes comprise a large family of transcription factors that have been implicated in normal and malignant hematopoiesis. However, data on their expression or function during T-cell develo...

    T Taghon, K Thys, M De Smedt, F Weerkamp, F J T Staal, J Plum, G Leclercq in Leukemia (2003)

  20. Article

    Open Access

    A novel germline mutation of PTEN associated with brain tumours of multiple lineages

    We have identified a novel germline mutation in the PTEN tumour suppressor gene. The mutation was identified in a patient with a glioma, and turned out to be a heterozygous germline mutation of PTEN (Arg234Gln...

    F J T Staal, R B van der Luijt, M R M Baert, J van Drunen… in British Journal of Cancer (2002)

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