Skip to main content

3 Result(s)

within P Jaako Remove this filter

and

  1. No Access

    Article

    Induction of the 5S RNP–Mdm2–p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia

    Mutations resulting in constitutive activation of signaling pathways that regulate ribosome biogenesis are among the most common genetic events in acute myeloid leukemia (AML). However, whether ribosome biogen...

    P Jaako, A Ugale, M Wahlestedt, T Velasco-Hernandez, J Cammenga, M S Lindström… in Leukemia (2017)

  2. No Access

    Article

    Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

    Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-m...

    P Jaako, S Debnath, K Olsson, Y Zhang, J Flygare, M S Lindström, D Bryder… in Leukemia (2015)

  3. No Access

    Article

    SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q-myelodysplastic syndrome

    K Siva, P Jaako, K Miharada, E Rörby, M Ehinger, G Karlsson, S Karlsson in Leukemia (2012)