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  1. No Access

    Article

    SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines

    CD23 acts through the αvβ5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. αvβ5 is expressed on normal B-cell precursors in the bone marrow. Soluble CD23 (sCD23), short ...

    M Acharya, A L Edkins, B W Ozanne, W Cushley in Leukemia (2009)

  2. No Access

    Article

    TGF-β-mediated activation of RhoA signalling is required for efficient V12HaRas and V600EBRAF transformation

    Transforming growth factor β-1 (TGF-β) acts as both a tumour suppressor and a tumour promoter in a context-dependent manner. The tumour-promoting activities of TGF-β are likely to result from a combination of ...

    Y M Fleming, G J Ferguson, L C Spender, J Larsson, S Karlsson, B W Ozanne… in Oncogene (2009)

  3. No Access

    Article

    p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism

    Loss of E-cadherin-mediated cell–cell junctions has been correlated with cancer cell invasion and poor patient survival. p120-catenin has emerged as a key player in promoting E-cadherin stability and adherens ...

    I R Macpherson, S Hooper, A Serrels, L McGarry, B W Ozanne, K Harrington… in Oncogene (2007)

  4. No Access

    Article

    Transcription factors control invasion: AP-1 the first among equals

    Metastasis, the aggressive spread of a malignant tumor to distant organs, is a major cause of death in cancer patients. Despite this critical role in cancer outcomes, the molecular mechanisms that control this...

    B W Ozanne, H J Spence, L C McGarry, R F Hennigan in Oncogene (2007)

  5. No Access

    Article

    Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function

    Cancer cells can invade three-dimensional matrices by distinct mechanisms, recently defined by their dependence on extracellular proteases, including matrix metalloproteinases. Upon treatment with protease inh...

    N O Carragher, S M Walker, L A Scott Carragher, F Harris, T K Sawyer… in Oncogene (2006)

  6. No Access

    Article

    The CD23a and CD23b proximal promoters display different sensitivities to exogenous stimuli in B lymphocytes

    The single human CD23 gene encodes two protein products differing by six or seven amino acids in the extreme N-terminal cytoplasmic domain. The patterns of expression of CD23a and CD23b transcripts differs as ...

    M-A Ewart, B W Ozanne, W Cushley in Genes & Immunity (2002)