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Article
A new method for optimising polarisation point in electrochemical impedance based measurements
In this work, we show a new procedure to obtain an optimum DC polarisation potential that allows achieving the maximum possible sensitivity for analyte determination, when electrochemical techniques are used. ...
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Article
Open AccessPathobiological implications of the d16HER2 splice variant for stemness and aggressiveness of HER2-positive breast cancer
We have previously shown that the d16HER2 splice variant is linked to HER2-positive breast cancer (BC) tumorigenesis, progression and response to Trastuzumab. However, the mechanisms by which d16HER2 contribut...
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Article
CD49d prevails over the novel recurrent mutations as independent prognosticator of overall survival in chronic lymphocytic leukemia
CD49d, the alpha-chain of the integrin heterodimer α4β1, was identified among the strongest predictors of overall survival (OS) in chronic lymphocytic leukemia (CLL), along with IGHV mutational status and deletio...
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Article
Open AccessHuman responses against HER-2-positive cancer cells in human immune system-engrafted mice
Human immune system (HIS)-engrafted mice are new tools to investigate human immune responses. Here, we used HIS mice to study human immune responses against human HER-2-positive cancer cells and their ability ...
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Article
Tear proteomics in evaporative dry eye disease
To analyze tear protein variations in patients suffering from dry eye symptoms in the presence of tear film instability but without epithelial defects.
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Article
ADI nutritional recommendations for dysphagia
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Article
Artificial nutrition: technical, scientific and ethical considerations
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Article
CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity
CD99 gene encodes two distinct proteins, produced by alternative splicing of CD99 gene transcript. Full-length CD99 isoform (CD99wt) is formed by an extracellular domain, followed by a transmembrane domain and a ...
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Article
CD49d in B-cell chronic lymphocytic leukemia: correlated expression with CD38 and prognostic relevance
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Article
Reply to Pittner et al.
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Article
Mutational status of IgVH genes in B-cell chronic lymphocytic leukemia and prognosis: percent mutations or antigen-driven selection?
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Article
Synthesis and characterization of BaSn(OH)6 and BaSnO3 acicular particles
The synthesis of BaSn(OH)6 acicular crystals by precipitation at 100 °C from aqueous solutions and their transformation in the perovskitelike compound BaSnO3 was investigated. Single acicular crystals 100–200 μm ...
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Article
Effect of Isovalent Ba-Site Substitutions on the Properties of (Ba1 – x – y M y Y x )TiO3(M = Ca, Sr, Pb) PTCR Ceramics
An approach is proposed for fabricating fine-grained, low-resistivity BaTiO3-based PTCR ceramics via partial isovalent substitutions on the Ba site. The grain size of the ceramics thus prepared is shown to decrea...
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Article
The preparation of porous perovskite membranes using BaTiO3 nanopowders
The aim of this study was to develop a simple and reliable procedure in order to prepare composite membranes through the deposition of thin porous layers of perovskite-like oxides onto ceramic porous supports....
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Article
Therapy of lung metastases through combined vaccination with carcinoma cells engineered to release IL-13 and IFN-γ
TS/A spontaneous mouse mammary adenocarcinoma cells were engineered to release interferon-γ (IFN-γ), a Th1 cytokine (TS/A-IFNγ) and interleukin-13 (IL-13), a Th2 cytokine (TS/A-IL13). Mice bearing lung micrometas...
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Article
Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination
The HER-2/neu proto-oncogene is overexpressed in 20–30% of human breast cancers and is associated with high recurrence risk. The oncogenic potential of HER-2/neu, together with its elevated expression in tumor...
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Strategies for Enhancing Tumor Immunogenicity (or how to transform a tumor cell in a Frankenstenian APC)
The immunological approach to cancer therapy springs from the observation that the onset and growth of a tumor are events so strictly connected with immune reactivity as to be markedly influenced by it. Signif...
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Article
Wild-type p53-mediated down-modulation of interleukin 15 and interleukin 15 receptors in human rhabdomyosarcoma cells
We recently reported that rhabdomyosarcoma cell lines express and secrete interleukin 15 (IL-15), a tightly regulated cytokine with IL-2-like activity. To test whether the p53-impaired function that is frequen...
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Article
Synthesis, sintering and expansion of Al0.8Mg0.6Ti1.6O5: a low-thermal-expansion material resistant to thermal decomposition
A low-thermal-expansion ceramic with the composition Al0.8Mg0.6Ti1.6O5 that is isostructural to aluminium titanate Al2TiO5, was prepared by solid-state reaction of a mixture of α-Al2O3, MgO and TiO2-rutile. Th...
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Article
Therapy of murine mammary carcinoma metastasis with interferon γ and MHC gene-transduced tumour cells
Gene-transfected tumour cells were used to cure mice bearing lung metastases by the parental, non-transduced mammary adenocarcinoma (TSA-pc). Repeated subcutaneous (s.c.) administrations of mitomycin C (MitC)-...