26 Result(s)

Article

CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity

CD99, a transmembrane protein encoded by MIC2 gene is involved in multiple cellular events including cell adhesion and migration, apoptosis, cell differentiation and regulation of protein trafficking either in ph...

C Zucchini, M C Manara, R S Pinca, P De Sanctis, C Guerzoni, M Sciandra… in Oncogene (2014)

Article

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling

Identification of patient selection criteria and understanding of the potential mechanisms involved in the development of resistance are crucial for an appropriate and successful design of clinical trials with...

C Garofalo, M C Manara, G Nicoletti, M T Marino, P-L Lollini, A Astolfi… in Oncogene (2011)

Article

CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity

CD99 gene encodes two distinct proteins, produced by alternative splicing of CD99 gene transcript. Full-length CD99 isoform (CD99wt) is formed by an extracellular domain, followed by a transmembrane domain and a ...

K Scotlandi, M Zuntini, M C Manara, M Sciandra, A Rocchi, S Benini, G Nicoletti… in Oncogene (2007)

Article

PET detection of epidermal growth factor receptor in colorectal cancer: a real predictor of response to cetuximab treatment?

M. A. Pantaleo, S. Fanti, P. L. Lollini… in European Journal of Nuclear Medicine and M… (2007)

Chapter and Conference Paper

Genetic Algorithm Against Cancer

We present an evolutionary approach to the search for effective vaccination schedules using mathematical computerized model as a fitness evaluator. Our study is based on our previous model that simulates the C...

F. Pappalardo, E. Mastriani, P. -L. Lollini, S. Motta in Fuzzy Logic and Applications (2006)

Chapter and Conference Paper

Model Deconstruction of an Immunoprevention Vaccine

We present a further step in develo** an in silico model that simulates the immune system responses to tumor cells in vaccinated mice. Our study is based on our previous model that simulates the cancer – immune...

F. Pappalardo, P. -L. Lollini, S. Motta, E. Mastriani in Advances in Natural Computation (2006)

Article

Therapy of lung metastases through combined vaccination with carcinoma cells engineered to release IL-13 and IFN-γ

TS/A spontaneous mouse mammary adenocarcinoma cells were engineered to release interferon-γ (IFN-γ), a Th1 cytokine (TS/A-IFNγ) and interleukin-13 (IL-13), a Th2 cytokine (TS/A-IL13). Mice bearing lung micrometas...

C De Giovanni, G Nicoletti, L Landuzzi, I Rossi, A Astolfi, C Ricci… in Gene Therapy (2001)

Chapter

Strategies for Enhancing Tumor Immunogenicity (or how to transform a tumor cell in a Frankenstenian APC)

The immunological approach to cancer therapy springs from the observation that the onset and growth of a tumor are events so strictly connected with immune reactivity as to be markedly influenced by it. Signif...

F. Cavallo, P. Nanni, P. Dellabona, P. L. Lollini, G. Casorati, G. Forni in Gene Therapy (1999)

Article

Wild-type p53-mediated down-modulation of interleukin 15 and interleukin 15 receptors in human rhabdomyosarcoma cells

We recently reported that rhabdomyosarcoma cell lines express and secrete interleukin 15 (IL-15), a tightly regulated cytokine with IL-2-like activity. To test whether the p53-impaired function that is frequen...

C De Giovanni, P Nanni, A Sacchi, S Soddu, I Manni, G D'Orazi… in British Journal of Cancer (1998)

Article

Therapy of murine mammary carcinoma metastasis with interferon γ and MHC gene-transduced tumour cells

Gene-transfected tumour cells were used to cure mice bearing lung metastases by the parental, non-transduced mammary adenocarcinoma (TSA-pc). Repeated subcutaneous (s.c.) administrations of mitomycin C (MitC)-...

P Nanni, C De Giovanni, L Landuzzi, G Nicoletti, F Frabetti… in British Journal of Cancer (1996)

Article

Redundancy of autocrine loops in human rhabdomyosarcoma cells: induction of differentiation by suramin

Three human rhabdomyosarcoma cell lines were used to investigate the presence of autocrine loops based on the production of insulin-like growth factor (IGF)-II, basic fibroblast growth factor (bFGF) and epider...

C De Giovanni, C Melani, P Nanni, L Landuzzi, G Nicoletti… in British Journal of Cancer (1995)

Article

Decreased adhesion to endothelial cells and matrix proteins of H-2K^b gene transfected tumour cells

Transfection of murine metastatic B78H1 cells (derived from B16 melanoma) with a syngeneic H-2Kb gene was used to study the effect of Major Histocompatibility Complex (MHC) gene products on tumour cell adhesio...

D Lauri, C De Giovanni, T Biondelli, E Lalli, L Landuzzi… in British Journal of Cancer (1993)

Article

Uncoupling of growth inhibition and differentiation in dexamethasone-treated human rhabdomyosarcoma cells

The effects of dexamethasone, a synthetic glucocorticoid, and of N,N-dimethylformamide on in vitro growth and differentiation and on proto-oncogene expression of human rhabdomyosarcoma cells were studied. RD/1...

C De Giovanni, P-L Lollini, R Dolcetti, L Landuzzi… in British Journal of Cancer (1993)

Article

Control of H-2 expression in transformed nonhaemopoietic cells by autocrine interferon

The relationship between autocrine interferon (IFN) production and the expression of class I Major Histocompatibility Complex (MHC) membrane glycoproteins in vitro was investigated in a panel of murine transfo...

P Nanni, L Landuzzi, G Nicoletti, C De Giovanni, M Giovarelli… in British Journal of Cancer (1992)

Article

Induction of myogenic differentiation in human rhabdomyosarcoma cells by ionising radiation, N,N-dimethylformamide and their combination

Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more...

G Nicoletti, C De Giovanni, L Landuzzi, G Simone, P Rocchi… in British Journal of Cancer (1992)

Article

In vitro differentiation of rhabdomyosarcomas induced by nickel or by Moloney murine sarcoma virus

In vitro cultures and clonal derivatives have been established from rat rhabdomyosarcomas induced by Moloney-Murine Sarcoma Virus (MSV) or by nickel sulfide; differentiation ability has been studied as express...

P Nanni, G Azzarello, L Tessarollo, C De Giovanni, P-L Lollini… in British Journal of Cancer (1991)