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Open AccessEvaluation of a large set of patients with Autoimmune Polyglandular Syndrome from a single reference centre in context of different classifications
To characterize patients with APS and to propose a new approach for their follow-up. Query ID="Q1" Text="Please check the given names and familynames."
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Article
Open AccessComputerized tomography texture analysis of pheochromocytoma: relationship with hormonal and histopathological data
Pheochromocytomas are rare tumors which can present with heterogeneous secretion profiles, clinical manifestations, and radiologic appearance. Under a histopathological point of view, they can be characterized...
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Article
Predictors of disease recurrence after curative surgery for nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNENs): a systematic review and meta-analysis
Patients submitted to curative surgery for non-functioning pancreatic neuroendocrine neoplasms (NF-PanNENs) exhibit a variable risk of disease relapse. Aims of this meta-analysis were to estimate the rate of d...
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Article
Time domain astronomy with the THESEUS satellite
THESEUS is a medium size space mission of the European Space Agency, currently under evaluation for a possible launch in 2032. Its main objectives are to investigate the early Universe through the observation ...
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Article
Diabetes mellitus induced by immune checkpoint inhibitors: type 1 diabetes variant or new clinical entity? Review of the literature
Immune Check-Point Inhibitors (CPIs) have improved long-term patients’ outcomes in several advanced cancers. Diabetes mellitus induced by CPIs (CPI-DM) is considered the second most frequent endocrine CPIs’ si...
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Article
Thr92Ala polymorphism in the type 2 deiodinase gene: an evolutionary perspective
In the past, a role of thyroid hormones in human evolution has been hypothesized. T3, the metabolically active form, derives from extrathyroidal conversion of T4 by deionidase 2 (D2) enzyme encoded by DIO2 gene. ...
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Article
Open AccessSearching for novel multimodal treatments in oligometastatic pancreatic cancer
Metastatic pancreatic cancer has a median overall survival of less than 12 months, even if treated with chemotherapy. Selected patients with oligometastatic disease could benefit from multimodal treatments con...
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Article
Open AccessOxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XFe96 Extracellular Flux Analyzer
Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and tim...
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Article
Prognostic Impact of MCPyV and TIL Subty** in Merkel Cell Carcinoma: Evidence from a Large European Cohort of 95 Patients
Merkel cell carcinoma is a rare (∼ 2000 cases/year in the USA) but aggressive neuroendocrine neoplasm of the skin. In 2008, the Merkel cell polyomavirus (MCPyV) was found to be clonally integrated in approxima...
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Article
Variants in MCT10 protein do not affect FT3 levels in athyreotic patients
Several single-nucleotide polymorphisms in genes encoding for transporters have been associated with serum thyroid hormone concentrations with inconsistent results. The aim of this study was to assess the clin...
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Article
The “Coptic” textiles of the “Museo Egizio” in Torino (Italy): a focus on dyes through a multi-technique approach
The Coptic textile collection of the Museo Egizio in Torino (Italy) has been the object of a broad project aimed at investigating the production techniques, at documenting the conservation state and at reconsi...
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Article
Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents
Immune activation contributes to the persistent state of inflammation associated with metabolic dysfunction in obesity. The specific immune receptors that sense metabolic stress signals and trigger inflammatio...
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Article
Natural occurrence of Fusarium proliferatum on chestnut in Italy and its potential entomopathogenicity against the Asian chestnut gall wasp Dryocosmus kuriphilus
The Asian chestnut gall wasp Dryocosmus kuriphilus (DK) is one of the most important pests of chestnut trees worldwide, and sustainable control measures are urgently required for its control. In this study, the ...
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Article
Multiple sclerosis in Italy: cost-of-illness study
This study estimates the direct costs of multiple sclerosis (MS) in Italy from the perspective of the National Health System. Patients diagnosed with MS for ≥1 year prior to study entry were included in the an...
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Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease
Podocyte loss by apoptosis, in addition to favouring progression of established diabetic nephropathy, has been recently indicated as an early phenomenon triggering the initiation of glomerular lesions. This st...
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Article
Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation
AGEs have been implicated in renal disease associated with ageing, diabetes and other age-related disorders. Reactive oxygen species (ROS) promote formation of AGEs, which cause AGE-receptor-mediated ROS gener...
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Article
40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Article
Effects of Zinc on Brown Fat Thermal Response to Cold in Normal and Triiodothyronine-Treated Hypothyroid Rats
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Therapy of lung metastases through combined vaccination with carcinoma cells engineered to release IL-13 and IFN-γ
TS/A spontaneous mouse mammary adenocarcinoma cells were engineered to release interferon-γ (IFN-γ), a Th1 cytokine (TS/A-IFNγ) and interleukin-13 (IL-13), a Th2 cytokine (TS/A-IL13). Mice bearing lung micrometas...
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Diagnosis of Helicobacter pylori infection: faecal antigen determination
Helicobacter pylori is a human pathogen that causes chronic gastritis, has a role in gastric and duodenal ulcer, is involved in gastric carcinogenesis and the bacteria have been classified as a cla...