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Chapter
Respiratory Carcinogenesis in Rats after Inhalation of Radioactive Aerosols of Actinides and Lanthanides in Various Physicochemical Forms
To study the role of the distribution of local tissue irradiation on the toxicity of alpha emitters, groups of 50 to 165 rats were exposed to aerosols of 244Cm(NO3)3, 241Am(NO3)3, 238Pu(NO3)4, 235Pu(NO3)4, 239PuO
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Chapter
Lesions and Lung Cancers Induced in Rats by Inhaled Radon 222 at Various Equilibriums with Radon Daughters
To investigate the dose-effect relationships, rats were exposed to several dose levels of radon at different levels of equilibrium with radon decay products, after inhalation of stable cerium hydroxide, and in...
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Article
Complete or almost complete analogy of chromosome banding between the baboon (Papio papio) and man
The karyotype of the baboon (Papio papio) was studied using several staining techniques: Q bands, R bands, T bands, C bands, G 11.6 bands, and after incorporation of BrdU. When compared with the karyotypes of the...
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Chapter
Modulation of Tumor Growth and Metastasis by an Acute Inflammation
Many studies have led to the conclusion that macrophage can contribute in a variety of ways to host resistance against tumors. Non immune inflammation represents the major mechanism by which indirect activatio...
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Chapter
Effect of an acute inflammatory process on tumour development
Since the pioneer work of Metchnikoff it has become well established that a non-immunological inflammation can increase host resistance against infection1. However, little is known about the efffect of such an in...
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Chapter
Effect of tumour growth on inflammatory macrophages
Studies in many laboratories have led to the speculation that macrophages probably play a significant role in host defence against neoplasia. It has been shown both in vitro and in vivo that macrophages can destr...
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Article
Bone tumours induced in rats with radioactive cerium
A technique is described for the induction of metastasizing bone tumours in rats by local inoculation of 144cerium. Bone sarcomas develop in 90% of the animals and 74% of these had lung metastases. The tumours...
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Article
Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons
Intratracheal administration of PAF-acether (60 μg.kg−1) was performed in six premedicated, curarized and mechanically ventilated baboons. Whereas intratracheal administration of an equal amount of solvent (200μl...
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Chapter
Lung Carcinogenesis During in Vivo Cigarette Smoking and Radon Daughter Exposure in Rats
The carcinogenic activity of tobacco smoke is clearly demonstrated by human epidemiologic data. Whereas in experimental animals tracheobronchial applications or injections of tars produce cancerous lesions, in...
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Chapter and Conference Paper
The Use of Neutron Radiography and Microdensitometry in the Study of Instrumental Effectiveness on Dental Tissue in the Process of Mineralization
In this study, neutron-radiography is used as a non-destructive method of exposing the peripheral part of the root canal which, in the course of endodontic treatment, is to be removed by root therapy instrumen...
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Chapter
Effect of Chronic Administration of a Synthetic Aromatic Retinoid (Ro 10-9359) on the Development of Lung Squamous Metaplasia and Epidermoid Cancer in Rats
Since the first studies of Saffioti et al. (1) suggesting the preventive effect of high doses of vitamin A on squamous metaplasias of trachea and bronchis, several authors have used synthetic analogs of vitami...
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Chapter
Cocarcinogenic Effect of Tobacco Smoke in Rats
The use of an animal model for investigating the induction of lung cancer by tobacco smoke in man is open to many objections, and epidemiology has already established a connection. Society might therefore rega...
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Article
Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats
This study describes the effect of intratracheal instillations (2 X 5 mg) of benzo(a)pyrene (B(a)P) on lung carcinogenesis in rats which had previously inhaled different levels of 239 plutonium oxide (220, 630...
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Chapter
An Integrated Gas Chromatographic-Mass Spectrometric Screening Method for Anabolic Steroid Urinary Metabolites in Man
For at least 3000 years, it has been a common practice to use various substances in attempts to increase physical prowess1. Since the mid-1970’s, an upsurge in the use of anabolic steroids has occured, due in par...
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Article
Metabolism of hydroxybiphenyl and chloro-hydroxybiphenyl by biphenyl/chlorobiphenyl degradingPseudomonas testosteroni, strain B-356
A biphenyl (BP) and chlorobiphenyl (CBP) metabolizingPseudomonas testosteroni, strain B-356 was also capable of utilizing 2-, 3-, and 4-hydroxybiphenyl. Data presented here suggest that utilization of biphenyl an...
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Article
Lung cancer in laboratory animals
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Chapter and Conference Paper
Carcinogenic Effects in Rats of Exposure to Different Minerals from Metallic Mine Ores, Radon and Radon Daughters
Combined exposure to radon and mineral dust is very common in some mine environments. It has been suggested that the carcinogenic activity of some inorganic materials might be related to their surface reducing...
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Chapter and Conference Paper
Unscheduled DNA synthesis (UDS) induced in vitro by cadmium in tracheal epithelial cells of rat and hamster
Cadmium (Cd) is an ubiquitous pollutant of industry and environment. It is known to damage various organs such as bones, lungs and kidneys in m a n and experimental animals (Paterson 1947; Friberg et al., 1986...
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Article
Prenatal or lactational exposure of male rats to lead acetate. Effect on reproductive function
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Article
RBE for carcinogenesis following exposure to high LET radiation
Stochastic radiation effects following exposure to heavy ions and other high linear energy transfer (LET) radiation in space are a matter of concern when the long-term consequences of space flights are conside...
