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Article
Interaction of smoking and radon in rats: a biologically based mechanistic model
Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and...
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Article
Age-adjustment in experimental animal data and its application to lung cancer in radon-exposed rats
Procedures for age-adjustment of cancer fractions are proposed which do not require fixed age intervals. The full available information on survival times can then be used, which is especially important in smal...
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Article
Lung tumour risk in radon-exposed rats from different experiments: comparative analysis with biologically based models
Data sets of radon-exposed male rats from Wistar and Sprague-Dawley strains have been investigated with two different versions of the two-step clonal expansion (TSCE) model of carcinogenesis. These so-called i...
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Chapter and Conference Paper
Carcinogenic Effects in Rats of Exposure to Different Minerals from Metallic Mine Ores, Radon and Radon Daughters
Combined exposure to radon and mineral dust is very common in some mine environments. It has been suggested that the carcinogenic activity of some inorganic materials might be related to their surface reducing...