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Article
Multichannel automatic foetal movement monitoring and classification system
The purpose of this work was to develop a compact, noninvasive and objective tool for foetal movement monitoring and classification. Four tocodynamometers were used as movement transducers and their output sig...
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Article
Anin vitro effect of an acute non-specific inflammatory serum on rat lymphocytes proliferative response to PHA
This study has demonstrated that serum obtained from animals undergoing an acute inflammatory reaction induced by an intrapleural injection of dextran is able to modulate the proliferative response to PHA of l...
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Article
Antitumor activity of living or killed Brucella: Modification of the non-specific cytotoxic effector cells
At various times after injection of living or killed smooth (S) or rough (R) Brucella abortus mice received a graft of the semi-allogenic EL4 lymphoma and their survival was studied. In parallel, the NK activity ...
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Chapter
Effect of Chronic Administration of a Synthetic Aromatic Retinoid (Ro 10-9359) on the Development of Lung Squamous Metaplasia and Epidermoid Cancer in Rats
Since the first studies of Saffioti et al. (1) suggesting the preventive effect of high doses of vitamin A on squamous metaplasias of trachea and bronchis, several authors have used synthetic analogs of vitami...
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Chapter
Three New Agents for Immunotherapy Trials: Azimexon, Bestatin, and Tuftsin
Cancer immunotherapy trials in man have almost exclusively been conducted with BCG, C. parvum, and MER (methanol extract residue of BCG)]19]. Not only did the clinical researchers meet difficulties concerning tol...
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Article
Macrophage activation by tuftsin and muramyl-dipeptide
Peritoneal macrophages from tuftsin or MDP-treated mice were tested for their cytostatic activity for tumor cell proliferation. Both substances are able to activate macrophages either after intravenous injecti...
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Chapter
Macrophage activation by tuftsin and muramyl-dipeptide
Peritoneal macrophages from tuftsin or MDP-treated mice were tested for their cytostatic activity for tumor cell proliferation. Both substances are able to activate macrophages either after intravenous injecti...
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Chapter and Conference Paper
In Vivo Immunostimulating Properties of Two Retinoids: Ro 10-9359 and Ro 13-6298
Vitamin A and some synthetic derivatives exhibit numerous activities; they have been recognized as an important factor in the differentiation of epithelial tissues (12,13); they possess an antiproliferative ef...
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Chapter
Modification of antibody responses during non-specific acute inflammation (Abstract)
It has been previously shown that non-specific acute inflammatory reactions are able to modify the activity of lymphocytes and macrophages. In the present work we investigated whether such a reaction could int...
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Chapter
Modulation of Tumor Growth and Metastasis by an Acute Inflammation
Many studies have led to the conclusion that macrophage can contribute in a variety of ways to host resistance against tumors. Non immune inflammation represents the major mechanism by which indirect activatio...
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Chapter
Progress in Experimental Systemic Active Immunotherapy of Cancer
A short review is presented of animal models used in cancer immunotherapy. Attention is focused on spontaneous canine tumors submitted to active immunotherapy after surgery, and on the use of immunorestoring a...
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Chapter
Correction of Immunodeficiency in Aged Mice by Levamisole and Bestatin Administration
An attempt to correct the impaired immune functions of aged mice was made by injecting repeatedly (over a 6-month period) two chemically defined immunostimu-lating agents, levamisole and bestatin, into 12- to ...
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Chapter
In Vivo Immunomodulating Properties of Two Synthetic Agents: Azimexon and Tuftsin
Mice were submitted to various immunologic tests at different times after a single intravenous (IV) injection of azimexon or tuftsin in order to determine the mode of action of these chemically defined immunom...
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Chapter
Effect of an acute inflammatory process on tumour development
Since the pioneer work of Metchnikoff it has become well established that a non-immunological inflammation can increase host resistance against infection1. However, little is known about the efffect of such an in...
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Chapter
Third Generation of Systemic Adjuvants of Immunity: Experimental Basis for Adjuvant Combinations
We already discussed in another paper in this Volume the rational experimental and clinical basis of specific and nonspecific immunotherapy [15]. We have compared the respective value of BCG and that of agents...
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Chapter
Post-Surgical Systematic Active Immunotherapy: Rational and Experimental Basis
Those who accepted the preliminary results of postsurgical chemotherapy of minimal residual disease (MRD) with too much enthusiasm now feel deceived since the number of beneficial chemotherapy trials has not i...
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Article
In vivo immunostimulation by tuftsin
Tuftsin, a physiological basic tetrapeptide known for its capacity to stimulate the phagocytic activity of macrophages and polymorphonuclear leucocytes, was examined for its immunostimulating properties when i...
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Chapter
The E(AkR)-Leukemia as Murine Model of Human Acute Lymphoid Leukemia for Immunotherapy Trials
Effectiveness of active immunotherapy with systemic administration of BCG has been confirmed in many animal tumor systems as well as in the treatment of acute lymphocytic leukemias and melanomas (reviewed by M...
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Chapter and Conference Paper
The E(AkR)-Leukemia as Murine Model of Human Acute Lymphoid Leukemia for Immunotherapy Trials
Effectiveness of active immunotherapy with systemic administration of BCG has been confirmed in many animal tumor systems as well as in the treatment of acute lymphocytic leukemias and melanomas (reviewed by M...
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Article
Experimental basis of BCG systemic immunotherapy
