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Article
Response of particle-associated bacteria to long-term heavy metal contamination in a tropical estuary
Estuaries being the connecting link between terrestrial and marine environment, experience spatial variations in the hydrographic variables as well as concentrations of pollutants. The present study reports a ...
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Article
Neuroendocrine and immunotoxicity of polyaromatic hydrocarbon, chrysene in crustacean post larvae
Polyaromatic hydrocarbons are a group of chemical pollutants which cause a significant threat to the living organisms in estuaries and marine ecosystems. We report the effect of chrysene, a major PAH pollutant...
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Article
Open AccessDiversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea
Marine sediments accommodate plethora of diverse microorganisms with varying ecological functions. In the present study, we isolated bacteria from surficial sediments of south east Arabian Sea (AS) and evaluat...
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Article
Characterization of an extracellular alkaline serine protease from marine Engyodontium album BTMFS10
An alkaline protease from marine Engyodontium album was characterized for its physicochemical properties towards evaluation of its suitability for potential industrial applications. Molecular mass of the enzyme b...
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Article
Molecular cloning and homology modelling of a subtilisin-like serine protease from the marine fungus, Engyodontium album BTMFS10
An alkaline protease gene (Eap) was isolated for the first time from a marine fungus, Engyodontium album. Eap consists of an open reading frame of 1,161 bp encoding a prepropeptide consisting of 387 amino acids w...
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Article
Pourquoi se soucier des personnes âgées: l’exemple du cancer
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Article
CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells
Ligation of the cell surface molecule CD44 by anti-CD44 monoclonal antibodies (mAbs) has been shown to induce cell differentiation, cell growth inhibition and in some cases, apoptosis in myeloid leukemic cells...
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Article
CD44 ligation induces apoptosis via caspase- and serine protease-dependent pathways in acute promyelocytic leukemia cells
We have recently reported that ligation of the CD44 cell surface antigen with A3D8 monoclonal antibody (mAb) triggers incomplete differentiation and apoptosis of the acute promyelocytic leukemia (APL)-derived ...
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Article
Unusual interleukin-4 and -13 signaling in human normal and tumor lung fibroblasts
IL-4 and IL-13 act on human lung fibroblasts through specific receptors differing in their composition. Indeed, the γc chain is constitutively expressed in tumor lung myofibroblast but not in normal cells. Her...
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Article
Cloning of a long HIV-1 readthrough transcript and detection of an increased level of early growth response protein-1 (Egr-1) mRNA in chronically infected U937 cells
To identify the pathways involved in HIV-1 modification of cellular gene expression, chronically infected U937 cells were screened by mRNA differential display. A chimeric transcript consisting of the 3′ end o...
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Article
6-day continuous infusion of high-dose ifosfamide with bone marrow growth factors in advanced refractory malignancies
Ifosfamide is an analogue of cyclophosphamide active in the treatment of numerous tumours. Although its use by continuous infusion seems to be responsible for less toxicity, differences of efficacy and toxicit...
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Article
Autocrine IL-2-dependent growth of a newly established CD3+, CD16−, CD56+, CD57+, JH−, TCRβ−, TCRγ− leukemia cell line (NOI-90)
Leukemic cells from a 45-year-old male patient with a CD3+, CD56+, CD57+, CD7+ acute lymphoblastic leukemia were cultured in vitro in the absence of any added growth factor for up to 6 years and a continuous lymp...
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Chapter and Conference Paper
How IL-2 can affect melanoma cells
Interleukin-2 (IL-2) is a T cell derived lymphokine strictly required for T lymphocytes proliferation. In T cells, it delivers a growth signal through a specific receptor (IL-2-Rαβ) which binds IL-2 with high aff...
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Chapter and Conference Paper
Expression and Role of Surface Markers of Immunocompetent Cells in Non Lymphoid Systems
The α and β chains of the Interleukin 2 receptor (IL2Rα and IL2Rβ) were detected at the surface of cultured melanoma and fibroblastic cells by flow cytometry, using monoclonal antibodies (mAbs) directed against t...
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Chapter and Conference Paper
Tumor Stem Cells and the Curability of Early Human Breast Cancer
Stem cell models of malignant tumors have been based on the existence of three categories of cells within the total tumor cell population: (a) proliferating, self-renewing stem cells, (b) proliferating, non-se...
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Article
Inhibition of human immunodeficiency virus (HIV) type 1 multiplication by an avian cellular factor
A factor secreted from avian cells infected non productively with a non cytopathogenic mutant of vesicular stomatitis virus (VSV ts 1026) interferes with HIV replication in CEM cells and peripheral blood monoc...
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Chapter
Oxalatoplatinum (I-OHP): Experimental and Clinical Studies
1,2 diamino cychlohexane (trans-I) oxalatoplatinum II was isolated by Kidani among isomeric mixture of DACH derivatives of Platinum as yielding the highest survival increment on L1210 leukemia.
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Chapter and Conference Paper
Involvement of the Interleukin 2/Interleukin 2-receptor system in the proliferation of human immature leukemic T cells
The mechanisms regulating the proliferation of immature T cells are yet elucidated. Previous studies investigating the involvement of IL2/IL2-R system presented evidence that some subsets of human thymocytes (CD2
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Chapter and Conference Paper
Interleukin-2 (IL-2) After Autologous Bone Marrow Transplantation (BMT):A Pilot Study of Late Administration, 2–3 Months Post ABMT
Association of high-dose radiotherapy ± chemotherapy can cure poor risk hematological neoplasias and solid tumors. This cure is related to the treatment dose effect as well as to the immunological effect (graf...
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Article
Late abstracts 186–187