Abstract
The use of an animal model for investigating the induction of lung cancer by tobacco smoke in man is open to many objections, and epidemiology has already established a connection. Society might therefore regard the use of animals in such a way as perverse and persecuting. However, the failure to resolve the problem as to why it is so difficult to induce lung carcinoma in rodents by the inhalation of tobacco smoke remains unsolved despite extensive trials and the use of ever more sophistocated smoking machines. It is however, easy to produce carcinoma in rats and hamsters by the intratracheal injection of smoke condensates.
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© 1984 Plenum Press, New York
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Masse, R., Chameaud, J., Lafuma, J. (1984). Cocarcinogenic Effect of Tobacco Smoke in Rats. In: Cumming, G., Bonsignore, G. (eds) Smoking and the Lung. Ettore Majorana International Science Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2409-6_4
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DOI: https://doi.org/10.1007/978-1-4613-2409-6_4
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