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Article
Stimulation of natural killer cytotoxicity by long-term treatment with double-stranded polynucleotides without induction of hyporesponsiveness
Treatment of Wistar/AG rats with a single i.p. injection of 1 mg/kg of synthetic double-stranded polynucleotides, either polyadenylic-polyuridylic acid (rAn.rUn), or a mismatched analogue of polyinosinic-polycyti...
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Chapter
Effect of Chronic Administration of a Synthetic Aromatic Retinoid (Ro 10-9359) on the Development of Lung Squamous Metaplasia and Epidermoid Cancer in Rats
Since the first studies of Saffioti et al. (1) suggesting the preventive effect of high doses of vitamin A on squamous metaplasias of trachea and bronchis, several authors have used synthetic analogs of vitami...
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Chapter
Modulation of Tumor Growth and Metastasis by an Acute Inflammation
Many studies have led to the conclusion that macrophage can contribute in a variety of ways to host resistance against tumors. Non immune inflammation represents the major mechanism by which indirect activatio...
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Chapter
Effect of an acute inflammatory process on tumour development
Since the pioneer work of Metchnikoff it has become well established that a non-immunological inflammation can increase host resistance against infection1. However, little is known about the efffect of such an in...
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Chapter
Effect of tumour growth on inflammatory macrophages
Studies in many laboratories have led to the speculation that macrophages probably play a significant role in host defence against neoplasia. It has been shown both in vitro and in vivo that macrophages can destr...
