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  1. No Access

    Article

    Melatonin injected into rat efficiently synchronizes the rhythm of protein synthesis in primary hepatocyte cultures isolated from this rat

    Melatonin injected intraperitoneally into rat synchronizes the ultradian rhythm of protein synthesis after 100 min in primary hepatocyte cultures isolated from this rat, which are studied after 1 or 2 days. Th...

    V. Ya. Brodsky, S. I. Rapoport, T. K. Dubovaya… in Russian Journal of Developmental Biology (2010)

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    Article

    Effect of Protein Synthesis Rhythm-Organizing Signal Persists for a Day after Single Administration of Melatonin to Rat

    Melatonin administered to rat intraperitoneally organizes ultradian rhythm of protein synthesis in hepatocytes that persists for 1 day after exposure to the synchronizing signal. Hepatocytes were isolated 1 da...

    N. D. Zvezdina, L. A. Malchenko… in Bulletin of Experimental Biology and Medic… (2014)

  3. No Access

    Article

    Glutamic acid – amino acid, neurotransmitter, and drug – is responsible for protein synthesis rhythm in hepatocyte populations in vitro and in vivo

    Primary cultures of rat hepatocytes were studied in serum-free media. Ultradian protein synthesis rhythm was used as a marker of cell synchronization in the population. Addition of glutamic acid (0.2 mg/ml) to...

    V. Y. Brodsky, L. A. Malchenko, D. S. Konchenko, N. D. Zvezdina… in Biochemistry (Moscow) (2016)

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    Article

    Glutamic acid as enhancer of protein synthesis kinetics in hepatocytes from old rats

    Dense cultures of hepatocytes from old rats (~2 years old, body weight 530-610 g) are different from similar cultures of hepatocytes from young rats by the low amplitude of protein synthesis rhythm. Addition o...

    V. Y. Brodsky, L. A. Malchenko, N. N. Butorina… in Biochemistry (Moscow) (2017)

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    Article

    Glutamic Acid Signal Synchronizes Protein Synthesis Kinetics in Hepatocytes from Old Rats for the Following Several Days. Cell Metabolism Memory

    The kinetics of protein synthesis was investigated in primary cultures of hepatocytes from old rats in serum–free medium. The rats were fed mixed fodder supplemented with glutamic acid and then transferred to ...

    V. Y. Brodsky, L. A. Malchenko, D. S. Lazarev, N. N. Butorina… in Biochemistry (Moscow) (2018)

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    Article

    Neuroprotective Peptides Regulate Protein-Synthesis Kinetics in Hepatocytes of Different Age Rats

    In the search for stable factors regulating direct cell–cell interactions and effects on the properties of cells in aging organisms, the regulatory peptides Semax and HLDF-6 were studied. The circahoralian rhy...

    V. Y. Brodsky, Y. A. Zolotarev, L. A. Malchenko… in Russian Journal of Developmental Biology (2019)

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    Article

    Melatonin Stimulates Epithelium Migration in Wound Models In Vitro and In Vivo

    We studied the effect of bovine brain gangliosides, individual ganglioside GM1, and melatonin on the rate of wound closure under in vitro conditions and the effect of melatonin on the rate of wound healing under

    E. A. Vorotelyak, L. A. Malchenko… in Bulletin of Experimental Biology and Medic… (2019)

  8. No Access

    Article

    The Administration of Semax and HLDF-6 Peptides to Rats Regulates Protein Synthesis Rhythm in Hepatocytes and Corrects Senescent Disturbances

    To clarify the organizing effect of Semax and HLDF-6 peptides on the kinetics of protein synthesis in hepatocytes, in addition to an in vitro study (Brodsky et al., 2019), the effects of these peptides in vivo...

    V. Y. Brodsky, Y. A. Zolotarev, L. A. Malchenko… in Russian Journal of Developmental Biology (2020)

  9. No Access

    Article

    Effects of Haloperidol and Cyproheptadine on the Cytoskeleton of the Sea Urchin Embryos

    Early sea urchin embryos are sensitive to agonists and antagonists of transmitter receptors, both metabotropic and channel ones. In this work, we studied mechanisms of the cytostatic action of cyproheptadine a...

    D. A. Nikishin, L. A. Malchenko… in Biochemistry (Moscow), Supplement Series A… (2020)

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    Article

    Oocyte-Mediated Effect of Serotonin on the Functional Status of Granulosa Cells

    In the mammalian ovary, serotonin has all the components necessary for its signaling function and affects the functional activity of granulosa cells. At the same time, the accumulation of serotonin with the he...

    D. A. Nikishin, Y. V. Khramova, N. M. Alyoshina… in Russian Journal of Developmental Biology (2021)

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    Article

    The Serotonin System in Mammalian Oogenesis

    Transmitters, particularly serotonin, not only have the classical function of transmitting nerve impulses, but also take part in a whole series of regulatory processes throughout ontogeny, including those occu...

    Yu. B. Shmukler, N. M. Alyoshina, L. A. Malchenko… in Neuroscience and Behavioral Physiology (2022)

  12. No Access

    Article

    Analysis of the Ovarian Marker Genes Expression Revealed the Antagonistic Effects of Serotonin and Androstenedione on the Functional State of Mouse Granulosa Cells in Primary Culture

    Primary culture of granulosa cells is a prerequisite for a complete study of the normal functioning of the ovary and its pathologies. In this work, we selected the optimal protocol for obtaining a primary cult...

    N. M. Alyoshina, V. R. Rousanova… in Russian Journal of Developmental Biology (2023)