Melatonin administered to rat intraperitoneally organizes ultradian rhythm of protein synthesis in hepatocytes that persists for 1 day after exposure to the synchronizing signal. Hepatocytes were isolated 1 day after melatonin administration and cultured on coverslips in a serum-free medium. In 24 h in culture, the kinetics of protein synthesis was analyzed. In our previous experiments, we detected a rhythm in cells isolated in 1.5 h, but not in 3 days after melatonin administration to the rat. We have found that synchronization of oscillations of the protein synthesis intensity in vivo persists over 1 day after rat exposure to melatonin. Phenylephrine, an efficient synchronizer of protein synthesis in vitro, does not organize the rhythm in vivo.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 9, pp. 298-301, September, 2013
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Zvezdina, N.D., Malchenko, L.A., Konchenko, D.S. et al. Effect of Protein Synthesis Rhythm-Organizing Signal Persists for a Day after Single Administration of Melatonin to Rat. Bull Exp Biol Med 156, 323–326 (2014). https://doi.org/10.1007/s10517-014-2340-4
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DOI: https://doi.org/10.1007/s10517-014-2340-4